Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Highly proliferative fibroblasts forming fibrotic focus govern metastasis of invasive ductal carcinoma of the breast
Autore:
Hasebe, T; Sasaki, S; Imoto, S; Ochiai, A;
Indirizzi:
Natl Canc Ctr, Res Inst E, Div Pathol, Chiba 2778577, Japan Natl Canc CtrChiba Japan 2778577 st E, Div Pathol, Chiba 2778577, Japan Natl Canc Ctr, Res Inst E, Epidemiol & Biostat Div, Chiba 2778577, Japan Natl Canc Ctr Chiba Japan 2778577 ol & Biostat Div, Chiba 2778577, Japan Natl Canc Ctr Hosp E, Dept Surg, Chiba, Japan Natl Canc Ctr Hosp E ChibaJapan nc Ctr Hosp E, Dept Surg, Chiba, Japan
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 325 - 337
SICI:
0893-3952(200104)14:4<325:HPFFFF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOPATHOLOGICAL PROGNOSTIC PARAMETER; SCAR CANCERS; TUMOR SIZE; LYMPH-NODE; FOLLOW-UP; EXPRESSION; PROTEIN; SCLERODERMA; SURVIVAL; MIB-1;
Keywords:
angiogenesis; fibrotic focus; fibroblast; immunohistochemistry; invasive ductal carcinoma; Ki-67 antigen; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ochiai, A Natl Canc Ctr, Res Inst E, Div Pathol, Kashiwanoha 6-5-1, Chiba 2778577, Japan Natl Canc Ctr Kashiwanoha 6-5-1 Chiba Japan 2778577 8577, Japan
Citazione:
T. Hasebe et al., "Highly proliferative fibroblasts forming fibrotic focus govern metastasis of invasive ductal carcinoma of the breast", MOD PATHOL, 14(4), 2001, pp. 325-337

Abstract

We have already reported that invasive ductal carcinomas (IDCs) with fibrotic focus (FF) have more aggressive characteristics than those without FF, FF is composed of a mixture of fibroblasts and various amounts of collagen fibers, suggesting that highly proliferative fibroblasts forming FF increase the malignant potential of IDCs with FF, The purpose of this study was toexamine whether there is a difference of proliferative activity of fibroblasts forming and not forming FF, which plays an important role in the turnoff progression of IDCs, Two hundred three consecutive cases of IDC of the breast surgically treated at the National Cancer Center Hospital East formedthe basis for this study. The proliferative activity of the fibroblasts forming the FF was immunohistochemically evaluated bf using mouse MIB-1 monoclonal antibody against Ki-67 antigen, The MIB-1 labeling index (LI) is the percentage of fibroblasts forming FF that have positively stained nuclei, and 300 fibroblasts were counted in each FF, The significance of the proliferative activity of fibroblasts forming FF with regard to lymph hade metastasis (LNM) or distant-organ metastasis (DOM) was compared with well-known prognostic parameters. Multivariate analysis demonstrated that high MIB-1 LI of fibroblasts forming FF significantly increased the relative risk of LNM and the hazard rate of DOM (P <.001 and P =.009). The present study indicated that the metastatic ability of IDCs with FF is highly dependent on the proliferative activity of the fibroblasts forming FF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:16:09