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Titolo:
Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath
Autore:
Hansen, T; Petrow, PK; Gaumann, A; Keyszer, GM; Otto, M; Kirkpatrick, CJ; Kriegsmann, J;
Indirizzi:
Univ Mainz, Inst Pathol, D-55101 Mainz, Germany Univ Mainz Mainz GermanyD-55101 nz, Inst Pathol, D-55101 Mainz, Germany Univ Jena, Inst Pathol, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 iv Jena, Inst Pathol, D-6900 Jena, Germany Univ Halle Wittenberg, Dept Internal Med 1, Halle, Germany Univ Halle Wittenberg Halle Germany Dept Internal Med 1, Halle, Germany
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 318 - 324
SICI:
0893-3952(200104)14:4<318:EOCPCB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIGMENTED VILLONODULAR SYNOVITIS; RHEUMATOID-ARTHRITIS; MESSENGER-RNA; HUMAN OSTEOCLASTS; BONE-RESORPTION; IDENTIFICATION; METALLOPROTEINASES; IMMUNOHISTOCHEMISTRY; LOCALIZATION; PHOSPHATASE;
Keywords:
bone erosion; cathepsin B; cathepsin K; cystatin C; giant cell tumor of tendon sheath; osteoclast-like giant cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kriegsmann, J Univ Mainz, Inst Pathol, Langenbeckstr 1, D-55101 Mainz, Germany Univ Mainz Langenbeckstr 1 Mainz Germany D-55101 z, Germany
Citazione:
T. Hansen et al., "Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath", MOD PATHOL, 14(4), 2001, pp. 318-324

Abstract

The expression of cysteine proteinases cathepsins B and EC and of the endogenous inhibitor of cysteine proteinases, cystatin C, was investigated in tissue specimens of patients with giant cell tumor of tendon sheath (GCTTS). Expression of both enzymes was examined by immunohistochemistry in tissue specimens of 14 patients with GCTTS. Applying double-labeling techniques, the coexpression of cathepsin B and its major endogenous inhibitor cystatin C was additionally studied. Cells expressing the respective proteins were further characterized with the macrophage markers HAM56 and anti-CD68 (clonePG-M1). Cathepsin B could be detected in numerous HAM56-positive mononuclear cells (MC), but only in very few giant cells (GC). In contrast, cathepsin K was predominantly identified in GC that were also strongly immunoreactive for cystatin C and CD68, Coexpression of cathepsin B and cystatin C occurred only in a few MC. The strong expression of both cathepsin B and K suggests that in GCTTS, bone erosion might be mediated not only by pressure of the proliferative tissue, but also by matrix-degrading cysteine proteinases. Because previous studies showed that osteoclasts express high levels of CD68, cathepsin K, and cystatin C but not of cathepsin B, our study contributes to the view that GC of GCTTS and osteoclasts are closely associated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:42:46