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Titolo:
Genetic variability in responses to caloric restriction in animals and in regulation of metabolism and obesity in humans
Autore:
Allison, DB; Miller, RA; Austad, SN; Bouchard, C; Leibel, R; Klebanov, S; Johnson, T; Harrison, DE;
Indirizzi:
Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp, Obes Res Ctr, NewYork, NY 10025 USA Columbia Univ Coll Phys & Surg New York NY USA 10025 ewYork, NY 10025 USA Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA Univ Idaho, Dept Biol Sci, Moscow, ID 83843 USA Univ Idaho Moscow ID USA 83843 Idaho, Dept Biol Sci, Moscow, ID 83843 USA Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA Pennington Biomed ResCtr Baton Rouge LA USA 70808 on Rouge, LA 70808 USA Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
, volume: 56, anno: 2001,
pagine: 55 - 65
SICI:
1079-5006(200103)56:<55:GVIRTC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; FOOD RESTRICTION; LIFE-SPAN; IDENTICAL-TWINS; FAMILY MEMBER; AGING PROCESS; ENERGY-INTAKE; LONGEVITY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Allison, DB Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp, Obes Res Ctr, 1090 Amsterdam Ave,14th Floor, New York, NY 10025 USA Columbia Univ Coll Phys & Surg 1090 Amsterdam Ave,14th Floor New York NY USA 10025
Citazione:
D.B. Allison et al., "Genetic variability in responses to caloric restriction in animals and in regulation of metabolism and obesity in humans", J GERONT A, 56, 2001, pp. 55-65

Abstract

Panel 5 focused on genetic factors that might mediate or moderate the effects of caloric restriction (CR) on longevity. Panel members stated that currently there is limited information directly addressing these issues. Therefore, they focused attention on what studies could be done. In addition, the panel believed that certain conceptual issues merited clarification and focused attention on this issue. Human studies and studies of nonhuman modelorganisms were discussed. The panel found at least three reasons why it would be valuable to find genes that influence the (putative) longevity-promoting effect of CR in humans. Such knowledge would offer: (a) the ability topredict individual responses to CR; (b) increased understanding of physiological mechanisms; and (c) the potential to develop mechanism-based interventions to promote longevity or healthy aging. In addition, the panel emphasized several macro-level recommendations regarding research strategies to avoid, research strategies to emphasize, and resources needing development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:10:26