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Titolo:
Direct determination of s-carboxymethyl-1-cysteine in syrups by reversed-phase high-performance liquid chromatography
Autore:
Suntornsuk, L;
Indirizzi:
Mahidol Univ, Fac Pharm, Bangkok 10400, Thailand Mahidol Univ Bangkok Thailand 10400 , Fac Pharm, Bangkok 10400, Thailand
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 1, volume: 25, anno: 2001,
pagine: 165 - 170
SICI:
0731-7085(200104)25:1<165:DDOSIS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOCYSTEINE; CARBOXYMETHYLCYSTEINE; QUANTIFICATION; CYSTEINE; PLASMA;
Keywords:
s-carboxymethyl-1-cysteine; reversed-phase chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Suntornsuk, L Mahidol Univ, Fac Pharm, 447 Sri Ayudhaya Rd, Bangkok 10400,Thailand Mahidol Univ 447 Sri Ayudhaya Rd Bangkok Thailand 10400 and
Citazione:
L. Suntornsuk, "Direct determination of s-carboxymethyl-1-cysteine in syrups by reversed-phase high-performance liquid chromatography", J PHARM B, 25(1), 2001, pp. 165-170

Abstract

A simple reversed-phase high-performance liquid chromatography method was developed for the determination of s-carboxymethyl-1-cysteine in syrup preparations. The experiments were performed without specific sample pre-treatment. The LC conditions used were acetonitrile-10 mM sodium dihydrogenphosphate buffer, pH 2.0 (1.99, v/v) on a C-18 Inersil column with a flow rate of1.5 ml/min. Ultraviolet detection was carried out at 240 nm. The method showed excellent linearity (r(2) > 0.9998) over the concentration range tested (0.8-25.6 mg/ml) with good precision and accuracy (%R.S.D. 0.7%). Recoveries were good ( > 99%) with a limit of detection and limit of quantitation of 0.1 and 0.8 mg/ml. Other compositions in the syrup vehicle did not interfere the analysis of s-carboxymethyl-1-cysteine. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:59:22