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Titolo:
Spectrophotometric determination of benazepril hydrochloride and hydrochlorothiazide in binary mixture using second derivative, second derivative of the ratio spectra and chemometric methods
Autore:
El-Gindy, A; Ashour, A; Abdel-Fattah, L; Shabana, MM;
Indirizzi:
Suez Canal Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Ismailia 41522, Egypt Suez Canal Univ Ismailia Egypt 41522 Analyt Chem, Ismailia 41522, Egypt Ain Shams Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Cairo 11562, EgyptAin Shams Univ Cairo Egypt 11562 rmaceut Analyt Chem, Cairo 11562, Egypt Cairo Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Cairo 11562, Egypt Cairo Univ Cairo Egypt 11562 Pharmaceut Analyt Chem, Cairo 11562, Egypt Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt Cairo Univ Cairo Egypt 11562 arm, Dept Pharmacognosy, Cairo 11562, Egypt
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 2, volume: 25, anno: 2001,
pagine: 299 - 307
SICI:
0731-7085(200105)25:2<299:SDOBHA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERNARY MIXTURES; RESOLUTION; TABLETS;
Keywords:
benazepril hydrochloride; chemometrics; hydrochlorothiazide; second derivative spectrophotometry; second derivative of the ratio spectra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: El-Gindy, A Suez Canal Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Ismailia 41522, Egypt Suez Canal Univ Ismailia Egypt 41522 , Ismailia 41522, Egypt
Citazione:
A. El-Gindy et al., "Spectrophotometric determination of benazepril hydrochloride and hydrochlorothiazide in binary mixture using second derivative, second derivative of the ratio spectra and chemometric methods", J PHARM B, 25(2), 2001, pp. 299-307

Abstract

Different spectrophotometric methods are presented for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in pharmaceutical tablets. The first method depends on second derivative (D-2) ultraviolet spectrophotometry, with zero crossing and peak to base measurement. The second derivative amplitudes at 214.8 and 227.4 nm were selected for the assay of benazepril hydrochloride and hydrochlorothiazide. respectively. The second method depends on second derivative of the ratio spectra by measurement of the amplitudes at 241.2 and 273.2 nm for benazepril hydrochloride and hydrochlorothiazide respectively. Chemometric methods, classical least squares and principal component regression, were applied to analyze the mixture. Both the chemometric methods were applied to the zero and first orderspectra of the mixture. The proposed methods were successfully applied forthe determination of the two drugs in laboratory prepared mixtures and in commerical tablets. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:51:45