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Titolo:
Organ infectivity of Toxoplasma gondii in interferon-gamma knockout mice
Autore:
Norose, K; Mun, HS; Aosai, F; Chen, M; Hata, H; Tagawa, Y; Iwakura, Y; Yano, A;
Indirizzi:
Chiba Univ, Sch Med, Dept Parasitol, Chiba 280, Japan Chiba Univ Chiba Japan 280 iv, Sch Med, Dept Parasitol, Chiba 280, Japan Univ Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan
Titolo Testata:
JOURNAL OF PARASITOLOGY
fascicolo: 2, volume: 87, anno: 2001,
pagine: 447 - 452
SICI:
0022-3395(200104)87:2<447:OIOTGI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; ENDOGENOUS IFN-GAMMA; ANTIGEN PRESENTATION; AVIRULENT STRAIN; SMALL-INTESTINE; MELANOMA-CELLS; CONGENIC MICE; NITRIC-OXIDE; CYST NUMBER; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yano, A Chiba Univ, Sch Med, Dept Parasitol, Chiba 280, Japan Chiba Univ Chiba Japan 280 Med, Dept Parasitol, Chiba 280, Japan
Citazione:
K. Norose et al., "Organ infectivity of Toxoplasma gondii in interferon-gamma knockout mice", J PARASITOL, 87(2), 2001, pp. 447-452

Abstract

To determine the influence of interferon (IFN)-gamma on thr organ infectivity and on the genetic susceptibility of susceptible (C57BL/6) and resistant (BALB/c) strains after peroral infection with cysts of Toxoplasma gondii. IFN-gamma knockout (KO) mice in C57BL/6 and BALB/c backgrounds were utilized. The kinetics of the changes in T. gondii abundance were evaluated with a quantitative competitive polymerase chain reaction assay in various organs at different times after peroral infection. In IFN-gamma KO mice, a T. gondii-specific gene. SAG1, was detected in all organs examined, and the protozoan proliferated much more actively than in wild-type mice. The abundanceof T. gondii was much higher in mesenteric lymph nodes and the heart than in other organs. In contrast, in the nervous system organs and kidneys, only a weakly detectable reaction was observed. Toxoplasma gondii grew ar a more rapid rate in the organs of IFN-gamma KO C57BL/6 mice than in the organsof IFN-gamma KO BALB/c mice during the course of infection. Destruction ofthr IFN-gamma gene showed remarkable effects on the infectivity in both susceptible and resistant mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:32:36