Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prenatal undernutrition and postnatal growth are associated with adolescent thymic function
Autore:
McDade, TW; Beck, MA; Kuzawa, CW; Adair, LS;
Indirizzi:
Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Anthropol, Evanston, IL 60208 USA Univ N Carolina, Dept Pediat, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ina, Dept Pediat, Chapel Hill, NC USA Univ N Carolina, Dept Nutr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA olina, Dept Nutr, Chapel Hill, NC USA Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA lina Populat Ctr, Chapel Hill, NC USA Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 iv, Dept Anthropol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 4, volume: 131, anno: 2001,
pagine: 1225 - 1231
SICI:
0022-3166(200104)131:4<1225:PUAPGA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-ACTIVITY; IMMUNE FUNCTION; FETAL GROWTH; HUMAN THYMOPOIETIN; CELLULAR-IMMUNITY; ADULT DISEASE; BIRTH-WEIGHT; INFANTS; THYMOPENTIN; DEFICIENCY;
Keywords:
thymic factor; immune system; prenatal exposure delayed effects; growth and development; nutrition; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: McDade, TW Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Evanston, IL 60208 USA
Citazione:
T.W. McDade et al., "Prenatal undernutrition and postnatal growth are associated with adolescent thymic function", J NUTR, 131(4), 2001, pp. 1225-1231

Abstract

The fetal and early infant origins of a number of adult cardiovascular andmetabolic diseases have received considerable attention, but the long-termconsequences of early environments for human immune function have not beenreported. We investigated the effects of pre- and postnatal environments on thymic hormone production in adolescents participating in an ongoing longitudinal study in the Philippines. Prospective data collected at birth, during y 1 of life, in childhood and in adolescence were used to predict plasma thymopoietin concentration in 14- to 15-y-old adolescents (n = 103). Thymopoietin concentration was compared for small-for-gestational-age and appropriate-for-gestational-age individuals while controlling for a range of postnatal exposures. Prenatal undernutrition was significantly associated withreduced thymopoietin production in interaction with the duration of exclusive breast-feeding (P = 0.006). Growth in length during y 1 of life was positively associated with adolescent thymopoietin production (P = 0.002). These associations remained significant after adjusting for a range of potentially confounding variables. These findings provide support for the importance of fetal and early infant programming of thymic function, and suggest that early environments may have long-term implications for immunocompetence and adult disease risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 12:30:15