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Titolo:
Increased myocardial blood flow during acute exposure to simulated altitudes
Autore:
Kaufmann, PA; Schirlo, C; Pavlicek, V; Berthold, T; Burger, C; von Schulthess, GK; Koller, EA; Buck, A;
Indirizzi:
Univ Zurich Hosp, Ctr Cardiovasc, Dept Nucl Cardiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Nucl Med, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich, Inst Physiol, Zurich, Switzerland Univ Zurich Zurich Switzerland urich, Inst Physiol, Zurich, Switzerland
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 158 - 164
SICI:
1071-3581(200103/04)8:2<158:IMBFDA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMAL CORONARY VASOMOTION; NONINVASIVE QUANTIFICATION; CALCIUM-ANTAGONISTS; MODERATE ALTITUDE; ARTERY DISEASE; N-13 AMMONIA; ADENOSINE; HEMODYNAMICS; CIRCULATION; METABOLISM;
Keywords:
myocardial blood flow; high altitudes; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufmann, PA Univ Zurich Hosp, Ctr Cardiovasc, Dept Nucl Cardiol, Raemistr100, CH-8091Zurich, Switzerland Univ Zurich Hosp Raemistr 100 Zurich Switzerland CH-8091 and
Citazione:
P.A. Kaufmann et al., "Increased myocardial blood flow during acute exposure to simulated altitudes", J NUCL CARD, 8(2), 2001, pp. 158-164

Abstract

Background. Although only poor data er;ist on changes in myocardial blood flow (MBF) under acute hypoxia, patients with known coronary artery diseaseare advised not to exceed a moderate altitude exposure of about 2000 m above sea level. Methods and Results, We measured MBF with positron emission tomography using O15-labeled water in 8 healthy human volunteers (aged 26 +/- 3 years [mean +/- SDI) at baseline (450 m above sea level, Zurich, Switzerland) and during acute hypoxic hypoxemia induced by inhalation of 2 hypoxic gas mixtures corresponding to altitudes of 2000 and 4500 m, MBF remained unchanged at 2000 m (increase of 10%, not significant) hut increased significantly at 4500 m (628, P < ,001), exceeding the relative increase in rate pressure product,Conclusions. Our results may explain why exposure to an altitude of 2000 m(corresponding to the cabin pressure in most airplanes during flight) is clinically well tolerated, even by patients with reduced coronary flow reserve, such as those dth coronary artery disease. However, at an altitude of 4500 m, MBF increases significantly, supporting the recommendation that patients with impaired flow reserve avoid exposure to higher altitudes,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:55:10