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Titolo:
Medial geniculate, amygdalar and cingulate cortical training-induced neuronal activity during discriminative avoidance learning in rabbits with auditory cortical lesions
Autore:
Duvel, AD; Smith, DM; Talk, A; Gabriel, M;
Indirizzi:
Univ Illinois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois, Neurosci Program, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Neurosci Program, Urbana, IL 61801 USA Univ Illinois, Dept Psychol, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Dept Psychol, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 21, anno: 2001,
pagine: 3271 - 3281
SICI:
0270-6474(20010501)21:9<3271:MGAACC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTIVE-FIELD PLASTICITY; CONDITIONED HEART-RATE; IBOTENIC ACID LESIONS; LATERAL AMYGDALA; BASOLATERAL AMYGDALA; CENTRAL NUCLEUS; FEAR; BODY; ACQUISITION; PROJECTIONS;
Keywords:
lesions; rabbits; multisite neuronal activity; discriminative avoidance learning; medial geniculate nucleus; lateral amygdala; basolateral amygdala; cingulate cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Gabriel, M Univ Illinois, Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA Univ Illinois 405 N Mathews Urbana IL USA 61801 a, IL 61801 USA
Citazione:
A.D. Duvel et al., "Medial geniculate, amygdalar and cingulate cortical training-induced neuronal activity during discriminative avoidance learning in rabbits with auditory cortical lesions", J NEUROSC, 21(9), 2001, pp. 3271-3281

Abstract

This study addressed the neural mediation of discriminative avoidance learning, wherein rabbits step in a wheel apparatus in response to an acoustic conditional stimulus, the CS+, to avoid a foot shock, and they learn to ignore a different stimulus, the CS-, not followed by foot shock. Previously, muscimol-induced inactivation of the amygdala in the first session of training prevented learning during the inactivation and permanently blocked the development of discriminative training-induced neuronal activity (TIA) in the medial division of the medial geniculate nucleus (MGm). These results suggested that amygdalar neurons induce discriminative TIA in the MGm via basolateral (BL) amygdalar axonal projections to the auditory cortex. To test this hypothesis, the activity of neurons in the MGm was recorded during learning in rabbits with lesions of the auditory cortex. Recordings were also made in the lateral and BL amygdalar nuclei and in the cingulate cortex. Insupport of the hypothesis, discriminative learning in rabbits with lesionswas impaired significantly during early training sessions 1-4; in these same sessions, discriminative TIA was abolished in the MGm, the BL nucleus, and the anterior cingulate cortex. The lesions also blocked posterior cingulate cortical discriminative TIA in training sessions 1-2 but spared TIA in sessions 3-7. Lateral amygdalar neurons showed gradual development of discrimination that was not significantly affected by the lesions. The results demonstrate a critical role of auditory cortex in early discriminative learning and in the production of early discriminative TIA in multiple areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:59:35