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Titolo:
Fear and feeding in the nucleus accumbens shell: Rostrocaudal segregation of GABA-elicited defensive behavior versus eating behavior
Autore:
Reynolds, SM; Berridge, KC;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 21, anno: 2001,
pagine: 3261 - 3270
SICI:
0270-6474(20010501)21:9<3261:FAFITN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL STRIATUM; EXTRACELLULAR DOPAMINE; SELECTIVE ACTIVATION; LATERAL HYPOTHALAMUS; EFFERENT PROJECTIONS; INCENTIVE SALIENCE; PREFRONTAL CORTEX; FRONTAL-CORTEX; BINDING-SITES; BED NUCLEUS;
Keywords:
accumbens shell; GABA; food intake; reward; appetite; motivation; glutamate; dopamine; fear; defense; aggression; mesolimbic; microinjection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Reynolds, SM Univ Michigan, Dept Psychol, 580 Union Dr, Ann Arbor, MI 48109 USA Univ Michigan 580 Union Dr Ann Arbor MI USA 48109 I 48109 USA
Citazione:
S.M. Reynolds e K.C. Berridge, "Fear and feeding in the nucleus accumbens shell: Rostrocaudal segregation of GABA-elicited defensive behavior versus eating behavior", J NEUROSC, 21(9), 2001, pp. 3261-3270

Abstract

This study examined localization of positive versus negative motivational functions mediated by GABA circuits within the accumbens shell. Microinjections of a GABA(A) agonist (0, 25, 75, and 225 ng/0.5 mul muscimol) in rostral shell sites elicited appetitive increases in eating behavior. In contrast, microinjections in caudal shell sites elicited defensive burying or paw-treading behavior. Rats whose microinjections landed bilaterally outside ofthe accumbens shell did not display either behavior. Defensive treading elicited by caudal shell muscimol microinjection appeared to be a negative motivated response to threat (similar in parameters and orientation to normaldefensive burying of a threatening electrified shock prod). The nucleus accumbens shell thus appears functionally heterogeneous in coding motivational valence. The demonstration that muscimol elicits positive eating behaviorfrom rostral shell versus negative defensive behavior from caudal shell suggests in particular that GABAergic substrates of positive and negative types of motivated behavior in the nucleus accumbens shell are segregated along a rostrocaudal gradient.

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Documento generato il 10/04/20 alle ore 02:29:29