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Titolo:
3,4-Methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development
Autore:
Broening, HW; Morford, LL; Inman-Wood, SL; Fukumura, M; Vorhees, CV;
Indirizzi:
Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn Cincinnati OH USA 45229 , Cincinnati, OH 45229 USA Univ Cincinnati, Coll Med, Cincinnati, OH 45229 USA Univ Cincinnati Cincinnati OH USA 45229 oll Med, Cincinnati, OH 45229 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 21, anno: 2001,
pagine: 3228 - 3235
SICI:
0270-6474(20010501)21:9<3228:3(LAMI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONERGIC NEURONS; MDMA ECSTASY ABUSE; LONG-TERM; WATER MAZE; RAT-BRAIN; METHYLENEDIOXYMETHAMPHETAMINE MDMA; SPATIAL NAVIGATION; (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SUBSTITUTED AMPHETAMINES; MALNOURISHED RATS;
Keywords:
methylenedioxymethamphetamine; development; MDMA; ecstasy; amphetamines; serotonin; dopamine; learning and memory; spatial learning; sequential learning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Vorhees, CV Childrens Hosp Res Fdn, Div Dev Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn 3333 Burnet Ave Cincinnati OH USA 45229
Citazione:
H.W. Broening et al., "3,4-Methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development", J NEUROSC, 21(9), 2001, pp. 3228-3235

Abstract

Use of 3,4- methylenedioxymethamphetamine (MDMA; ecstasy) has increased dramatically in recent years, yet little is known about its effects on the developing brain. Neonatal rats were administered MDMA on days 1-10 or 11-20 (analogous to early and late human third trimester brain development). MDMAexposure had no effect on survival but did affect body weight gain during treatment. After treatment, body weight largely recovered to 90-95% of controls. MDMA exposure on days 11-20 resulted in dose-related impairments of sequential learning and spatial learning and memory, whereas neonatal rats exposed on days 1-10 showed almost no effects. At neither stage of exposure did MDMA-treated offspring show effects on swimming ability or cued learning. Brain region-specific dopamine, serotonin, and norepinephrine changes were small and were not correlated to learning changes. These findings suggest that MDMA may pose a previously unrecognized risk to the developing brainby inducing long-term deleterious effects on learning and memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:54:43