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Titolo:
Adaptive axonal remodeling in the midbrain auditory space map
Autore:
DeBello, WM; Feldman, DE; Knudsen, EI;
Indirizzi:
Univ Calif Davis, Ctr Neurosci, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Physiol & Behav, Davis, CA 95616 USA Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ept Neurobiol, Stanford, CA 94305 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 21, anno: 2001,
pagine: 3161 - 3174
SICI:
0270-6474(20010501)21:9<3161:AARITM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARN OWL; OPTIC TECTUM; INFERIOR COLLICULUS; VISUAL CALIBRATION; SOUND LOCALIZATION; INTERAURAL TIME; PLASTICITY; EXPERIENCE; XENOPUS; PROJECTION;
Keywords:
axon elaboration; axon elimination; anterograde tracing; biocytin; boutons; development; experience-dependent plasticity; inferior colliculus; synaptogenesis; topographic map;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: DeBello, WM Univ Calif Davis, Ctr Neurosci, Dept Neurobiol Physiol & Behav, 1544 Newton Court, Davis, CA 95616 USA Univ Calif Davis 1544 Newton CourtDavis CA USA 95616 5616 USA
Citazione:
W.M. DeBello et al., "Adaptive axonal remodeling in the midbrain auditory space map", J NEUROSC, 21(9), 2001, pp. 3161-3174

Abstract

The auditory space map in the external nucleus of the inferior colliculus (ICX) of barn owls is highly plastic, especially during early life. When juvenile owls are reared with prismatic spectacles (prisms) that displace thevisual field laterally, the auditory spatial tuning of neurons in the ICX adjusts adaptively to match the visual displacement. In the present study, we show that this functional plasticity is accompanied by axonal remodeling. The ICX receives auditory input from the central nucleus of the inferior colliculus (ICC) via topographic axonal projections. We used the anterogradetracer biocytin to study experience-dependent changes in the spatial pattern of axons projecting from the ICC to the ICX. The projection fields in normal adults were sparser and more restricted than those in normal juveniles. The projection fields in prism-reared adults were denser and broader thanthose in normal adults and contained substantially more bouton-laden axonsthat were appropriately positioned in the ICX to convey adaptive auditory spatial information. Quantitative comparison of results from juvenile and prism-reared owls indicated that prism experience led to topographically appropriate axonal sprouting and synaptogenesis. We conclude that this elaboration of axons represents the formation of an adaptive neuronal circuit. The density of axons and boutons in the normal projection zone was preserved in prism-reared owls. The coexistence of two different circuits encodingalternative maps of space may underlie the ability of prism-reared owls toreadapt to normal conditions as adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:47:44