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Titolo:
Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis
Autore:
Elhassan, AM; Adem, A; Papadogiannakis, N; Suliman, I; Gad, A; Lindgren, JU;
Indirizzi:
Karolinska Inst, Huddinge Hosp, Dept Orthoped Surg, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 d Surg, S-14186 Huddinge, Sweden United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pharmacol, Al Ain, U Arab Emirates United Arab Emirates Univ Al Ain U Arab Emirates l Ain, U Arab Emirates Karolinska Inst, Huddinge Hosp, Dept Pathol, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 Pathol, S-14186 Huddinge, Sweden
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 116, anno: 2001,
pagine: 15 - 20
SICI:
0165-5728(20010501)116:1<15:IAOSPA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; GROWTH-HORMONE SECRETION; BLOOD MONONUCLEAR-CELLS; SUBSTANCE-P; RHEUMATOID-ARTHRITIS; LYMPHOCYTES; PROLACTIN; MODULATION; RECEPTORS;
Keywords:
somatostatin; adjuvant; arthritis; synovium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Elhassan, AM Karolinska Inst, Huddinge Hosp, Dept Orthoped Surg, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 86 Huddinge, Sweden
Citazione:
A.M. Elhassan et al., "Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis", J NEUROIMM, 116(1), 2001, pp. 15-20

Abstract

The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the firstday of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteriainoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis andan anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:18:44