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Titolo:
Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues
Autore:
Miao, J; Panesar, NS; Chan, KT; Lai, FMM; Xia, NS; Wang, YB; Johnson, PJ; Chan, JYH;
Indirizzi:
Natl Yang Ming Univ, Inst Radiol Sci, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 nst Radiol Sci, Taipei 112, Taiwan Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept A&C Anat, Sir YK Pao Ctr Canc, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin HongKong Peoples R China Peoples R China Xiamen Univ, Dept Biol, Xiamen 361005, Peoples R China Xiamen Univ Xiamen Peoples R China 361005 Xiamen 361005, Peoples R China
Titolo Testata:
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
fascicolo: 4, volume: 49, anno: 2001,
pagine: 491 - 499
SICI:
0022-1554(200104)49:4<491:DEOASG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; SIGNAL-TRANSDUCTION PATHWAYS; NITRATE THERAPY; LEYDIG-CELLS; TNF-ALPHA; RAT; STEROIDOGENESIS; TESTIS; CORTEX; PML;
Keywords:
BRE; adrenal; steroid; stress response; neoplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, JYH Natl Yang Ming Univ, Inst Radiol Sci, Shi Pai, Taipei 112, Taiwan Natl Yang Ming Univ Shi Pai Taipei Taiwan 112 aipei 112, Taiwan
Citazione:
J. Miao et al., "Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues", J HIST CYTO, 49(4), 2001, pp. 491-499

Abstract

Genes that modulate the action of hormones and cytokines play a critical role in stress response, survival, and in growth acid differentiation of cells. Many of these biological response modifiers are responsible for variouspathological conditions, including inflammation, infection, cachexia, aging, genetic disorders, and cancer. We have previously identified a new gene,BRE, that is responsive to DNA damage and retinoic acid. Using multiple-tissue dot-blotting and Northern blotting, BRE was recently found to be strongly expressed in adrenal cortex and medulla, in testis, and in pancreas, whereas low expression was found in the thyroid, thymus, small intestine and stomach. In situ hybridization and immunohistochemical staining indicated that BRE was strongly expressed in the zona glomerulosa of the adrenal cortex, which synthesizes and secretes the mineralocorticoid hormones. It is also highly expressed in the glial and neuronal cells of the brain and in the round spermatids, Sertoli cells, and Ledig cells of the testis, all of which are associated with steroid hormones and/or TNF synthesis. However, BRE expression was downregulated in human adrenal adenoma and pheochromocytoma, whereas its expression was enhanced in abnormal adrenal tissues of rats chronically treated with nitrate or nitrite. These data, taken together, indicate that the expression of BRE is apparently associated with steroids and/or TNF production and the regulation of endocrine functions. BRE may play animportant role in the endocrine and immune system, such as the cytokine-endocrine interaction Of the adrenal gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:20