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Titolo:
Magnetic resonance spectroscopy in traumatic brain injury
Autore:
Brooks, WM; Friedman, SD; Gasparovic, C;
Indirizzi:
Univ New Mexico, Dept Neurosci, Clin & Magnet Resonance Res Ctr, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ Washington, Med Ctr, Ctr Anxiety & Depress, Dept Radiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Radiol, Seattle, WA 98195 USA Univ New Mexico, Nucl Magnet Resonance Lab, Clin & Magnet Resonance Res Ctr, Dept Neurosci, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NMUSA 87131 rosci, Albuquerque, NM 87131 USA
Titolo Testata:
JOURNAL OF HEAD TRAUMA REHABILITATION
fascicolo: 2, volume: 16, anno: 2001,
pagine: 149 - 164
SICI:
0885-9701(200104)16:2<149:MRSITB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE MAGNESIUM CONCENTRATION; CEREBRAL ENERGY-METABOLISM; INTRACELLULAR FREE MG-2+; PROTON MR SPECTROSCOPY; CLOSED-HEAD INJURY; N-ACETYL ASPARTATE; IN-VIVO; MITOCHONDRIAL DYSFUNCTION; NERVOUS-SYSTEM; AXONAL INJURY;
Keywords:
adenosine triphosphate; animal models; choline; magnetic resonance spectroscopy; N-acetylaspartate; neuroimaging; phosphocreatine; rehabilitation; traumatic brain injury;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, WM Univ New Mexico, Dept Neurosci, Clin & Magnet Resonance Res Ctr, Dept Psychol, 1201 Yale Blvd NE, Albuquerque, NM 87131 USA Univ New Mexico 1201 Yale Blvd NE Albuquerque NM USA 87131 USA
Citazione:
W.M. Brooks et al., "Magnetic resonance spectroscopy in traumatic brain injury", J HEAD TR R, 16(2), 2001, pp. 149-164

Abstract

Magnetic resonance spectroscopy (MRS) offers a unique non-invasive approach for assessing the metabolic status of the brain in vivo and is particularly suited to studying traumatic brain injury (TBI). In particular, MRS provides a noninvasive means for quantifying such neurochemicals as N-acetylaspartate (NAA, creatine, phosphocreatine, choline) lactate, myo-inositol, glutamine, glutamate, adenosine triphosphate (ATP), and inorganic phosphate inhumans following TBI and in animal models. Many of these chemicals have been shown to be perturbed following TBI. NAA, a marker of neuronal integrity, has been shown to be reduced following TBI, reflecting diffuse axonal injury or metabolic depression, and concentrations of NAA predict cognitive outcome. Elevation of choline-containing compounds indicates membrane breakdown or inflammation or both. MRS can also detect alterations in high energy phosphates reflecting the energetic abnormalities seen after TBI. Accordingly, MRS may be useful to monitor cellular response to therapeutic interventions in TBI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:43:20