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Titolo:
Migration and function of antigen-primed nonpolarized T lymphocytes in vivo
Autore:
Iezzi, G; Scheidegger, D; Lanzavecchia, A;
Indirizzi:
Inst Res Biomed, CH-6500 Bellinzona, Switzerland Inst Res Biomed Bellinzona Switzerland CH-6500 0 Bellinzona, Switzerland Hosp San Raffaele Sci Inst, Canc Immunotherapy Gene Therapy Program, I-20132 Milan, Italy Hosp San Raffaele Sci Inst Milan Italy I-20132 ram, I-20132 Milan, Italy Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 8, volume: 193, anno: 2001,
pagine: 987 - 993
SICI:
0022-1007(20010416)193:8<987:MAFOAN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY LYMPHOID ORGANS; T-HELPER-2 POPULATIONS; IMMUNOLOGICAL MEMORY; CELL-DIFFERENTIATION; POLARIZED T-HELPER-1; CHEMOKINE RECEPTORS; DENDRITIC CELLS; HELPER CELL; EXPRESSION; ACTIVATION;
Keywords:
migration; secondary response; T helper cell type 1; T helper cell type 2; nonpolarized T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Lanzavecchia, A Inst Res Biomed, Via Vela 6, CH-6500 Bellinzona, Switzerland Inst Res Biomed Via Vela 6 Bellinzona Switzerland CH-6500
Citazione:
G. Iezzi et al., "Migration and function of antigen-primed nonpolarized T lymphocytes in vivo", J EXP MED, 193(8), 2001, pp. 987-993

Abstract

Upon antigenic stimulation, naive T lymphocytes proliferate and a fractionof the activated cells acquire a T helper cell type 1 (Th1) or Th2 phenotype as well as the capacity to migrate to inflamed tissues. However, the antigen-primed T cells that receive a short T cell receptor (TCR) stimulation do not acquire effector function and remain in a nonpolarized state. Using TCR transgenic CD4(+) T cells in an adoptive transfer system, we compared the in vivo migratory capacities of naive, nonpolarized, Th1 or Th2 cells. Although all cell types migrated to the spleen, only naive and nonpolarized T cells efficiently migrated to lymph nodes. In addition Th1, but not Th2, migrated to inflamed tissues. In the lymph nodes, nonpolarized T cells proliferated and acquired effector function in response to antigenic stimulation, displaying lower activation threshold and faster kinetics compared with naive T cells. These results suggest that nonpolarized T cells are in an intermediate state of differentiation characterized by lymph node homing capacity and increased responsiveness that allows them to mount a prompt and effective secondary response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:25:26