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Titolo:
Target-derived BDNF (brain-derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus
Autore:
Von Bartheld, CS; Johnson, JE;
Indirizzi:
Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA Univ Nevada Reno NV USA 89557 ept Physiol & Cell Biol, Reno, NV 89557 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 433, anno: 2001,
pagine: 550 - 564
SICI:
0021-9967(20010514)433:4<550:TB(NFI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING VISUAL-SYSTEM; RETINAL GANGLION-CELLS; CENTRAL-NERVOUS-SYSTEM; CHICK-EMBRYOS; NITRIC-OXIDE; ANTEROGRADE TRANSPORT; RETROGRADE TRANSPORT; PROTEIN-SYNTHESIS; AXONAL-TRANSPORT; SENSORY DEFICITS;
Keywords:
neurotrophin; retrograde axonal transport; retina; visual system; cell death; chick embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Von Bartheld, CS Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Mailstop 352, Reno, NV 89557 USA Univ Nevada Mailstop 352 Reno NV USA 89557 , NV 89557 USA
Citazione:
C.S. Von Bartheld e J.E. Johnson, "Target-derived BDNF (brain-derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus", J COMP NEUR, 433(4), 2001, pp. 550-564

Abstract

Neurons in the peripheral nervous system depend on single neurotrophic factors, whereas those in the brain are thought to utilize many different trophic factors. This study examined whether some neurons in the brain critically depend on a single trophic factor during development. Neurons in the isthmo-optic nucleus (ION) of chick embryos respond to exogenous brain-derivedneurotrophic factor (BDNF). Relatively high concentrations of endogenous BDNF were present in the ION of 14-18-day-old chick embryos. ION target cells in the retina were immunolabeled for BDNF but showed surprisingly low levels of BDNF mRNA. These data suggest that ION target cells derive some BDNFfrom other retinal sources. No BDNF mRNA was detected in the ION itself. ION neurons had a very efficient retrograde transport system for BDNF and exogenous BDNF arrived in the ION intact. When the ION was deprived of endogenous trkB ligands by injection of trkB fusion proteins in the eye, cell death of ION neurons was enhanced, and this effect was mimicked by BDNF-specific blocking antibodies in the eye. TrkB fusion proteins in the retina induced cell death of ION neurons prior to visible effects on ION target cells in the retina. Immunolabel for endogenous BDNF was sparse in pyknotic ION neurons, suggesting that ION neurons with low BDNF content were eliminated byapoptosis. These data show that BDNF is an essential target-derived trophic factor for developing ION neurons and thereby validate the neurotrophic hypothesis for at least one neuronal population in the brain. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:31:12