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Titolo:
Liquid chromatography-tandem mass spectrometry method of urine analysis for determining human variation in carcinogen metabolism
Autore:
Knize, MG; Kulp, KS; Malfatti, MA; Salmon, CP; Felton, JS;
Indirizzi:
Univ Calif Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, Livermore, CA 94550 USA Univ Calif Lawrence Livermore Natl Lab Livermore CA USA 94550 A 94550 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 914, anno: 2001,
pagine: 95 - 103
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROCYCLIC AMINE CONTENT; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO<4,5-B>PYRIDINE PHIP; MEAT-PRODUCTS; COOKED FOODS; CHICKEN; IDENTIFICATION; EXCRETION; PROSTATE; CANCER; RATS;
Keywords:
amines, heterocyclic aromatic; aminomethylphenylimidazo[4,5-b]pyridine; pyridines; glucuronides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Knize, MG Univ Calif Lawrence Livermore Natl Lab, Biol & Biotechnol Res Program, POB5508, Livermore, CA 94550 USA Univ Calif Lawrence Livermore Natl Lab POB 5508 Livermore CA USA 94550
Citazione:
M.G. Knize et al., "Liquid chromatography-tandem mass spectrometry method of urine analysis for determining human variation in carcinogen metabolism", J CHROMAT A, 914(1-2), 2001, pp. 95-103

Abstract

We developed a solid-phase extraction LC-MS-MS method for the analysis of the four major metabolites of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pridine) in human urine after a meal of well-done chicken. Ten volunteers each ate either 150 or 200 g of well-done chicken breast containing 9-21 mugof PhIP. Among the individual volunteers there is 8-fold variation in the total amount of metabolites and 20-fold variation in the relative amounts of individual metabolites, showing individual differences in carcinogen metabolism. PhIP metabolites were also detected in urine from a subject consuming chicken in a restaurant meal, demonstrating the method's sensitivity after real-life exposures. Published by Elsevier Science B.V.

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Documento generato il 09/04/20 alle ore 07:39:19