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Titolo:
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters
Autore:
Moll, GH; Hause, S; Ruther, E; Rothenberger, A; Huether, G;
Indirizzi:
Univ Gottingen, Dept Child & Adolescent Psychiat, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 chiat, D-3400 Gottingen, Germany Univ Gottingen, Dept Adult Psychiat, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 chiat, D-3400 Gottingen, Germany
Titolo Testata:
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 15 - 24
SICI:
1044-5463(200121)11:1<15:EMATYR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NEUROTROPHIC FACTOR BDNF; MOUSE ASTROGLIAL CELLS; EARLY JUVENILE LIFE; MAGNETIC-RESONANCE; CAUDATE-NUCLEUS; UPTAKE SITES; BRAIN; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Huether, G Univ Gottingen, Dept Child & Adolescent Psychiat, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 00 Gottingen, Germany
Citazione:
G.H. Moll et al., "Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters", J CH AD PSY, 11(1), 2001, pp. 15-24

Abstract

Methylphenidate is widely and effectively used for the treatment of attention deficit hyperactivity disorder during early childhood and adolescence, but until now possible effects of this treatment on brain development and the maturation of monoaminergic systems have not been investigated systematically. This experimental animal study describes the effects of methylphenidate administration (2 mg/kg/day) for 2 weeks to very young (prepubertal) and somewhat older (postpubertal) rats on the densities of dopamine, serotonin, and norepinephrine transporters in the striatum and in the midbrain. As shown by ligand-binding-assays, the KD values of all three transporters were unaffected by this treatment. No alterations were found for the B-max values of [H-3]-paroxetine and [H-3]-nisoxetine binding, but the density of dopamine transporters (B-max values of [H-3]-GBR binding) in the striatum (but not in the midbrain) was significantly reduced after early methylphenidate administration (by 25% at day 45), and this decline reached almost 50% atadulthood (day 70), that is, long after termination of the treatment. Thisis the first empirical demonstration of long-lasting changes in the development of the central dopaminergic system caused by the administration of methylphenidate during early juvenile life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:13:41