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Titolo:
Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: A double-blind, placebo-controlled pilot trial
Autore:
Van Bellinghen, M; De Troch, C;
Indirizzi:
AZH Hart, Dept Child Psychiat, Psychotherapeut Ctr, Asse, Belgium AZH Hart Asse Belgium hild Psychiat, Psychotherapeut Ctr, Asse, Belgium
Titolo Testata:
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 5 - 13
SICI:
1044-5463(200121)11:1<5:RITTOB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA; HALOPERIDOL; MULTICENTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Van Bellinghen, M AZH Hart, Dept Child Psychiat, Psychotherapeut Ctr, Asse, Belgium AZH Hart Asse Belgium chotherapeut Ctr, Asse, Belgium
Citazione:
M. Van Bellinghen e C. De Troch, "Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: A double-blind, placebo-controlled pilot trial", J CH AD PSY, 11(1), 2001, pp. 5-13

Abstract

Risperidone, an antipsychotic agent with combined serotonin (5-HT2A) and dopamine (D-2) receptor-blocking properties, is associated with fewer extrapyramidal side effects in adults than conventional neuroleptics. Approved in1993 for the treatment of schizophrenia, recent studies have highlighted its potential in other conditions, such as the management of behavioral disturbances. This phase II, double-blind, placebo-controlled study evaluated the efficacy and tolerability of risperidone in the treatment of persistent behavioral disturbances in children with borderline intellectual functioning. Thirteen patients (6-14 years) with low IQ (66-85) were enrolled in and completed the 4-week study. Risperidone, in daily doses of greater than or equal to0.01 mg/kg (mean dose at treatment endpoint = 0.05 mg/kg; mean total dose = 1.2 mg/day), was significantly more effective than placebo in improving Aberrant Behavioral Checklist (ABC) symptom cluster scores for irritation (p < 0.05) and hyperactivity (p < 0.01), Clinical Global Impression score (p < 0.05), the Visual Analogue Scale score for individual target symptom (p < 0.001), and Personal Assessment Checklist scores for social relationships (p < 0.05) and occupational attitudes (p < 0.05). In addition, the improvement in total ABC score in the risperidone-treated group was clinically relevant (65% improvement vs. baseline), whereas the placebo-treated patients only improved 7% versus baseline. There was no difference between risperidone- and placebo-treated groups with respect to the occurrence of extrapyramidal side effects, and risperidone was well tolerated. In conclusion,short-term risperidone treatment was well tolerated and significantly moreeffective than placebo in controlling behavioral disturbances in children with low IQ.

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Documento generato il 22/01/20 alle ore 06:44:24