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Titolo:
Limitation of infarct size by fixed coronary arterial stenosis maintained during reperfusion
Autore:
Nanas, JN; Nanas, SN; Kontoyannis, DA; Moussoutzani, KS; Rapti, AC; Charitos, CE; Terrovitis, JV; Stamatelopoulos, SF; Moulopoulos, SD;
Indirizzi:
Univ Athens, Sch Med, Dept Clin Therapeut, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 in Therapeut, GR-11527 Athens, Greece
Titolo Testata:
JOURNAL OF CARDIOVASCULAR SURGERY
fascicolo: 1, volume: 42, anno: 2001,
pagine: 27 - 35
SICI:
0021-9509(200102)42:1<27:LOISBF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAAORTIC BALLOON COUNTERPULSATION; MYOCARDIAL BLOOD-FLOW; TISSUE PLASMINOGEN-ACTIVATOR; AORTIC COUNTERPULSATION; THROMBOLYTIC THERAPY; SUDDEN REPERFUSION; CARDIOGENIC-SHOCK; TL-201 KINETICS; OCCLUSION; TRIAL;
Keywords:
myocardial infarction; reperfusion injury; dogs; thrombolytic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nanas, JN Makedonias 24, Athens 10433, Greece Makedonias 24 Athens Greece 10433 ias 24, Athens 10433, Greece
Citazione:
J.N. Nanas et al., "Limitation of infarct size by fixed coronary arterial stenosis maintained during reperfusion", J CARD SURG, 42(1), 2001, pp. 27-35

Abstract

Background The effect on infarct size of a pre-infarction high-grade, fixed coronary arterial stenosis maintained during reperfusion, was evaluated. Methods. This experimental study was carried out in the research laboratory of a University Hospital. A canine occlusion-reperfusion model was used. Twenty-eight dogs underwent proximal left anterior descending (LAD) coronary artery occlusion (O). In Group 1 (n=6) the O lasted for 6 hours. In Group2 (n=6) the O lasted for 2 hours followed by 4 hours of reperfusion (R), In Group 3 (n=3), LAD was stenosed for 30 minutes followed by O for 6 hours. In Group 4 (n=7) LAD was stenosed for 30 minutes followed by O for 2 hoursand then 4 hours of R during which the artery was kept stenosed at the same degree (fixed) as the initial one. In Group 5 (n=6) the protocol was identical to Group 4 with the additional use of the intra-aortic balloon pump during R,Results, The infarcted myocardium was almost the same in Groups 1 and 3 (80.0 +/- 10.6% vs 77.3 +/-3.8%, respectively, p=NS), but less in Group 2 (59.0 +/- 19.9%, p=0.046 vs Group 1). There were no hemodynamic differences between Groups 4 and 5 and the infarcted myocardium was almost identical in both groups (37.7 +/- 18.8% and 38.7 +/- 19.1%, respectively, p=NS). The combined results of Groups 4 and 5, regarding the infarcted myocardium, was 38.1 +/- 18% (p=0.037 vs Group 2),Conclusions. In this acute coronary occlusion model, a pre-existing high-grade stenosis that maintained during reperfusion increased the amount of salvaged ischemic myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:36:27