Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes
Autore:
Sun, ZQ; Thomas, GP; Antzelevitch, C;
Indirizzi:
Masonic Med Res Lab, Utica, NY 13501 USA Masonic Med Res Lab Utica NY USA13501 c Med Res Lab, Utica, NY 13501 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 472 - 478
SICI:
1045-3873(200104)12:4<472:C2ISAD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-QT SYNDROME; BETA-ADRENERGIC AGONISTS; I-SK CHANNELS; K+ CURRENT; ENDOCARDIAL MYOCYTES; GENETIC VARIABLES; CARDIAC EVENTS; 2 COMPONENTS; KS; FORM;
Keywords:
inward rectifier current; delayed rectifier current; transient outward current; L-type calcium current; chromanol 293B; I-Ks; I-Kr;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Antzelevitch, C Masonic Med Res Lab, 2150 Bleecker St, Utica, NY 13501 USAMasonic Med Res Lab 2150 Bleecker St Utica NY USA 13501 SA
Citazione:
Z.Q. Sun et al., "Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes", J CARD ELEC, 12(4), 2001, pp. 472-478

Abstract

Introduction: Drugs that selectively inhibit the slowly activating component of the delayed rectifier potassium current (I-Ks) are being considered as possible antiarrhythmic agents, because they produce more prolongation ofaction potential duration at fast rates with less transmural dispersion ofrepolarization compared with blockers of the rapidly activating component (I-Kr), Although the chromanol derivative chromanol 293B has been shown to be relatively selective in blocking I-Ks in some species, its selectivity is far from established. Methods and Results: The present study uses whole-cell, patch-clamp technique to examine the selectivity of this compound for inhibition of I-Ks in comparison with other repolarizing ionic currents, such as I-Kr, inward rectifier potassium current (I-K1), transient outward current (I-to), and L-type calcium current (ICa-L) in canine left ventricular mid-myocardial and endocardial cells. Chromanol 293B blocked I-Ks with an IC50 of 1.8 muM and I-to with an IC50 of 38 muM. Concentrations as high as 30 muM did not affect I-K1, I-Kr, or ICa-L. Higher concentrations of chromanol 293B (100 muM) caused a slight, but statistically insignificant, inhibition of I-Kr. Conclusion: Our results indicate that chromanol 293B is a relatively selective blocker of I-Ks in canine left ventricular myocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:49:56