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Titolo:
Therapeutic drug monitoring in methadone maintenance: Choosing a matrix
Autore:
Moolchan, ET; Umbricht, A; Epstein, D;
Indirizzi:
NIDA, Dept Hlth & Human Serv, NIH, IRP,Clin Pharmacol & Therapeut Res Branch, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 Therapeut Res Branch, Baltimore, MD 21224 USA
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 2, volume: 20, anno: 2001,
pagine: 55 - 73
SICI:
1055-0887(2001)20:2<55:TDMIMM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-PROTEIN BINDING; STEADY-STATE PHARMACOKINETICS; HUMAN LIVER-MICROSOMES; N-DEMETHYLATION; MASS-SPECTROMETRY; CLINICAL PHARMACOKINETICS; ALPHA-1-ACID GLYCOPROTEIN; LIQUID-CHROMATOGRAPHY; COCAINE ABSTINENCE; ADAPTIVE-CHANGES;
Keywords:
methadone maintenance; opioid addiction; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Moolchan, ET NIDA, Dept Hlth & Human Serv, NIH, IRP,Clin Pharmacol & Therapeut Res Branch, 5500 Nathan Shock Dr,POB 5180, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr,POB 5180 Baltimore MD USA 21224 USA
Citazione:
E.T. Moolchan et al., "Therapeutic drug monitoring in methadone maintenance: Choosing a matrix", J ADDICT D, 20(2), 2001, pp. 55-73

Abstract

Methadone maintenance is the premier pharmacological treatment for opioid addiction, but it is rarely informed by evidence-based practice guidelines for dosage monitoring and adjustment. Such guidelines ale crucial because the pharmacokinetics of methadone vary greatly among patients, and this variation may account for differences in treatment outcome. We review the pharmacokinetics of methadone and factors that may alter it (including drug interactions, disease states, and idiosyncratic differences among patients). Also reviewed are prospects for therapeutic drug monitoring (TDM) of methadone in plasma, urine, sweat, and saliva. Due to its ease of collection and its presumed representation of the bioavailable free-fraction of methadone, saliva may be a promising matrix. However, saliva methadone concentrations are influenced by salivary pH, and future studies are needed to determine how to control for that. Administrative, medical, and social implications of methadone TDM are briefly discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:53:55