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Titolo:
The immune system, apoptosis and apoptosis-related proteins in human ovarian tumors (A review)
Autore:
Zusman, I; Gurevich, P; Gurevich, E; Ben-Hur, H;
Indirizzi:
Hebrew Univ Jerusalem, Koret Sch Vet Med, Expt Oncol Lab, Fac Agr Food & Environm Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Kaplan Med Ctr, Dept Gynecol & Obstet, Rehovot, Israel Kaplan Med Ctr Rehovot Israel r, Dept Gynecol & Obstet, Rehovot, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 18, anno: 2001,
pagine: 965 - 972
SICI:
1019-6439(200105)18:5<965:TISAAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAS-LIGAND; BCL-2 EXPRESSION; INFILTRATING LYMPHOCYTES; P53 EXPRESSION; CANCER-CELLS; CARCINOMAS; LESIONS; PROLIFERATION; GROWTH; COLON;
Keywords:
apoptosis; bcl-2; Fas; Fas ligand; p53; ovarian tumors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Zusman, I Hebrew Univ Jerusalem, Koret Sch Vet Med, Expt Oncol Lab, Fac Agr Food & Environm Sci, Box 12, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Box 12 Rehovot Israel IL-76100 ot, Israel
Citazione:
I. Zusman et al., "The immune system, apoptosis and apoptosis-related proteins in human ovarian tumors (A review)", INT J ONCOL, 18(5), 2001, pp. 965-972

Abstract

Our studies on the relationships among the lymphoid system, apoptosis and apoptosis-related proteins (ARP) in human ovarian benign cysts, borderline tumors, and carcinomas are reviewed and analyzed. Fas and Fas ligand are expressed in 50% to 80% of the epithelial cells in all studied tumors. Many bcl-2-positive tumor epithelial cells are seen in benign cysts and they disappear as tumorigenesis progresses, whereas p53 protein is found only in borderline tumors and in carcinomas. Many exceptions to the opinion that bcl-2inhibits apoptosis and p53 promotes it are encountered. Bcl-2 is lacking in epithelial cells of mucoid tumors of all grades, and its absence does notstimulate their apoptosis. P53 protein is absent from most lymphocytes, macrophages and epithelial tumor cells, nevertheless, they undergo apoptosis. Indeed, in many tumors apoptosis is regulated without the participation ofbcl-2 and p53. Different components of the immune system become active during different stages of tumor development. The weak reaction of T-cell killers and macrophages is typical in benign cysts. In borderline tumors, the activity of T-cell killers increases in the parenchyma, and that of T helpers and macrophages in the stroma. In carcinomas with high lymphoid infiltration, a strong reaction of macrophages and T cell killers in the tumoral parenchyma as well high reaction of T helpers and B lymphocytes in the stroma are typical. Apoptosis that should protect against tumor also stimulates apoptotic death of lymphocytes and macrophages, and this has catastrophic consequences, as seen in weakly infiltrated carcinomas. In conclusion, our studies indicate that during malignancy the major task of the immune system iscurtailment and control of tumorigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:10:01