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Titolo:
Expression of CD44 splice variants in spontaneous murine tumors
Autore:
Lockhart, MS; Cabrera, P; Diament, M; Alvarez, E; Klein, D; Hajos, SE;
Indirizzi:
Univ Buenos Aires, Fac Farm & Bioquim, Catedra Inmunol, IDEHU CONICET, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1113 Aires, DF, Argentina Inst Angel Roffo, Buenos Aires, DF, Argentina Inst Angel Roffo Buenos Aires DF Argentina , Buenos Aires, DF, Argentina
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 7, anno: 2001,
pagine: 557 - 562
SICI:
1107-3756(200105)7:5<557:EOCSVI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMING RECEPTOR; PARANEOPLASTIC SYNDROMES; LUNG ADENOCARCINOMA; PROGNOSTIC FACTOR; ALTERNATIVE EXON; GROWTH INVIVO; ISOFORMS; METASTASIS; LEUKEMIA; LYMPHOMA;
Keywords:
CD44; murine tumors; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hajos, SE Univ Buenos Aires, Fac Farm & Bioquim, Catedra Inmunol, IDEHU CONICET, Junin 956 4to Piso, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Junin 956 4to Piso Buenos Aires DF Argentina RA-1113
Citazione:
M.S. Lockhart et al., "Expression of CD44 splice variants in spontaneous murine tumors", INT J MOL M, 7(5), 2001, pp. 557-562

Abstract

CD44 is a widely distributed set of cell surface glycoproteins expressed in several types of cells and tissues, implicated in cell-cell and cell-substrate interactions. This molecule plays a major role in cell differentiation, development and activation and has also been described as a potential marker of malignancy and metastasis. In the present study we investigated by RT-PCR followed by exon specific amplification the expression of CD44 splice variants in four different murine tumors as well as in the invaded or ansin order to correlate the expression of CD44 variants with potential tumorinvasiveness and their implications for growth. Our data showed deregulation in the expression of CD44 isoforms but no discernible correlation in isoform expression pattern. However, in all tumors studied isoforms presented by the primary tumor were detected in the invaded organs before metastasis could be demonstrated by histopathological analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:30:13