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Titolo:
Serological markers for detection of cancer (Review)
Autore:
Zusman, I; Ben-Hur, H;
Indirizzi:
Hebrew Univ Jerusalem, Koret Sch Vet Med, Fac Agr Food & Environm Qual Sci, Expt Oncol Lab, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Kaplan Hosp, Dept Obstet & Gynecol, IL-76100 Rehovot, Israel Kaplan Hosp Rehovot Israel IL-76100 & Gynecol, IL-76100 Rehovot, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 7, anno: 2001,
pagine: 547 - 556
SICI:
1107-3756(200105)7:5<547:SMFDOC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM ANTI-P53 ANTIBODIES; CELL LUNG-CANCER; PROSTATE-SPECIFIC ANTIGEN; TUMOR-SUPPRESSOR GENE; INFLAMMATORY BOWEL-DISEASE; SOLUBLE P53 ANTIGEN; DNA ADDUCT LEVELS; 53 KDA PROTEIN; CARCINOEMBRYONIC ANTIGEN; COLORECTAL-CANCER;
Keywords:
cancer; early detection; monitoring; tumor markers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Zusman, I Hebrew Univ Jerusalem, Koret Sch Vet Med, Fac Agr Food & Environm Qual Sci, Expt Oncol Lab, Box 12, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Box 12 Rehovot Israel IL-76100 ot, Israel
Citazione:
I. Zusman e H. Ben-Hur, "Serological markers for detection of cancer (Review)", INT J MOL M, 7(5), 2001, pp. 547-556

Abstract

We reviewed the effectiveness of commercial serological markers for the early detection of cancer and monitoring cancer patients. Parameters, such asspecificity and variability of tumor markers were compared with a new approach for cancer detection which was recently developed in our laboratory. We demonstrate that the absence of tumor specificity and the extremely high variability of tumor markers are the reason that none of them can be used for early cancer diagnosis. We developed a method for the isolation of tumor-associated antigens (TAA) and found that two soluble low-molecular mass 66and 51 kDa proteins could be isolated from the blood of cancer patients. The first protein, albumin, belongs to a group of heat-shock proteins (HSP),while the second is connected with TAA. The progress in cancer is characterized by a relative decrease in the concentration of HSP and a high increase in blood levels of TAA. Our method was shown to be highly sensitive and specific for the early detection of different types of cancer, such as of the colon, uterus, ovary, and breast, as well as melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:43:08