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Titolo:
Histamine-induced activation of human lung macrophages
Autore:
Marone, G; Gentile, M; Petraroli, A; De Rosa, N; Triggiani, M;
Indirizzi:
Univ Naples Federico II, Div Clin Immunol & Allergy, I-80131 Naples, ItalyUniv Naples Federico II Naples Italy I-80131 ergy, I-80131 Naples, Italy V Monaldi Gen Hosp, Pathol Unit, Azienda Osped Monaldi, Naples, Italy V Monaldi Gen Hosp Naples Italy t, Azienda Osped Monaldi, Naples, Italy
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1-3, volume: 124, anno: 2001,
pagine: 249 - 252
SICI:
1018-2438(200101/03)124:1-3<249:HAOHLM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE FLUID; BETA-GLUCURONIDASE RELEASE; PERIPHERAL-BLOOD; MAST-CELLS; ASTHMA; RECEPTORS; H-2;
Keywords:
asthma; histamine; beta-glucuronidase; fexofenadine; macrophages; IL-6; exocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Marone, G Univ Naples Federico II, Div Clin Immunol & Allergy, Via Pansini5, I-80131 Naples, Italy Univ Naples Federico II Via Pansini 5 Naples Italy I-80131 taly
Citazione:
G. Marone et al., "Histamine-induced activation of human lung macrophages", INT A AL IM, 124(1-3), 2001, pp. 249-252

Abstract

Background: Histamine plays a central role in the pathogenesis of allergicand inflammatory diseases by modulating vascular and airway responses. Increasing evidence suggests that histamine also regulates the function of inflammatory and immune cells. Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages. Methods: Macrophages purified (>95%) from lung parenchyma byPercoll density gradients and adherence to polystyrene dishes were incubated (37 degreesC, 2-24 h) with histamine (10(-9)-10(-6) M). At the end of incubation, the release of beta -glucuronidase and IL-6 was determined. Results: Histamine induced a concentration-dependent release of beta -glucuronidase and IL-6 with a maximum release after 2 and 6 h of incubation, respectively. Exocytosis induced by histamine was noncytotoxic and was Ca2+- and temperature-dependent. The effect of histamine was inhibited by the H-1 receptor antagonist fexofenadine but not by the H-2 antagonist ranitidine. Conclusions: These data indicate that histamine is an effective stimulus for exocytosis and cytokine production from human lung macrophages. These effects are inhibited by pharmacological concentrations of fexofenadine. Our results suggest that histamine may contribute to the long-term evolution of lung inflammation and tissue remodelling in allergic diseases by modulating the production of proinflammatory and immunoregulatory mediators by macrophages. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:48:43