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Titolo:
The role of alpha-galactosylceramide-activated V alpha 14 natural killer Tcells in the regulation of Th2 cell differentiation
Autore:
Nakayama, T; Yamashita, M; Kawano, T; Shimizu, C; Shibata, Y; Kamata, T; Kaneko, Y; Kobayashi, S; Takeda, U; Motohashi, S; Cui, JQ; Taniguchi, M;
Indirizzi:
Chiba Univ, Grad Sch Med, Dept Mol Immunol, JST,CREST Project,Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 EST Project,Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1-3, volume: 124, anno: 2001,
pagine: 38 - 42
SICI:
1018-2438(200101/03)124:1-3<38:TROAVA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-E PRODUCTION; V(ALPHA)14 NKT CELLS; INTERFERON-GAMMA; MEDIATED ACTIVATION; RECEPTOR EXPRESSION; IGE PRODUCTION; IN-VIVO; ANTIGEN; MICE; INTERLEUKIN-4;
Keywords:
IgE; IFN-gamma; alpha-galactosylceramide; NKT cell; suppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Taniguchi, M Chiba Univ, Grad Sch Med, Dept Mol Immunol, JST,CREST Project,Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 2608670, Japan
Citazione:
T. Nakayama et al., "The role of alpha-galactosylceramide-activated V alpha 14 natural killer Tcells in the regulation of Th2 cell differentiation", INT A AL IM, 124(1-3), 2001, pp. 38-42

Abstract

V alpha 14 natural killer T (NKT) cells produce large amounts of both IL-4and IFN-gamma upon stimulation with a ligand, a galactosylceramide (alpha -GalCer), and play a crucial role in various immune responses, including allergic diseases. Interestingly, V alpha 14 NKT cells are not essential for the induction of IgE responses but rather induce suppression of specific IgE production upon activation. The suppression in the IgE production is not detected either in Va14 NKT cell-deficient mice or in IFN-gamma -deficient mice. Thus, activated V alpha 14 NKT cells are likely to exert a potent suppressive activity on Th2 cell differentiation and subsequent IgE productionby producing a large amount of IFN-gamma, In marked contrast, little regulatory effect of IL-4 produced by Va14 NKT cells on Th2 cell differentiationis suggested. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:27:49