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Titolo:
Unexpected functions of Fc epsilon RI on antigen-presenting cells
Autore:
Kraft, S; Katoh, N; Novak, N; Koch, S; Bieber, T;
Indirizzi:
Univ Bonn, Dept Dermatol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Dept Dermatol, D-53105 Bonn, Germany Kyoto Prefectural Univ Med, Dept Dermatol, Kyoto, Japan Kyoto Prefectural Univ Med Kyoto Japan Med, Dept Dermatol, Kyoto, Japan
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1-3, volume: 124, anno: 2001,
pagine: 35 - 37
SICI:
1018-2438(200101/03)124:1-3<35:UFOFER>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; HIGH-AFFINITY RECEPTOR; NF-KAPPA-B; ALLERGEN PRESENTATION; DENDRITIC CELLS; IGE; ACTIVATION; EXPRESSION; MONOCYTES; SKIN;
Keywords:
IgE receptor; antigen-presenting cells; apoptosis; NF-kappa B; dendritic cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bieber, T Univ Bonn, Dept Dermatol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 nn, Germany
Citazione:
S. Kraft et al., "Unexpected functions of Fc epsilon RI on antigen-presenting cells", INT A AL IM, 124(1-3), 2001, pp. 35-37

Abstract

In contrast to mast cells and basophils, the high affinity IgE receptor (Fc epsilon RI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- andtwo gamma -chains and enables APC to efficiently take up and present antigen in IgE-mediated delayed-type hypersensitivity reactions that are thoughtto play a pivotal role in atopic diseases. However, recent studies of Fc epsilon RI signal transduction and function on APC suggest additional mechanisms by which Fc epsilon RI engagement on APC could affect inflammatory reactions, FceRI ligation is able to induce major signaling events like protein tyrosine kinase activation including p72(syk) leading to PLC-yl phosphorylation and consecutive calcium influx. Late signaling events like the activation of transcription factors such as NF-KB provide a link to the release of proinflammatory cytokines and chemokines, Th-polarizing factors such as IL-12 and the induction of antiapoptotic factors, Fc epsilon RI-mediated IL-10 production in monocytes could also influence their differentiation. Since there are hints that in vivo a functional Fc epsilon RI signaling pathway only exists in individuals from an atopic background, we suggest that these unexpected mechanisms may have an effect on inflammatory reactions in atopic diseases. Copyright (C) 2001 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:07:34