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Titolo:
Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes arenoncompetitive
Autore:
Yamada, T; Uchiyama, H; Nagata, T; Uchijima, M; Suda, T; Chida, K; Nakamura, H; Koide, Y;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Microbiol & Immunol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Internal Med 2, Hamamatsu, Shizuoka 4313192,Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 u, Shizuoka 4313192,Japan
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 5, volume: 69, anno: 2001,
pagine: 3427 - 3430
SICI:
0019-9567(200105)69:5<3427:PCTLRI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-RESTRICTED PEPTIDES; ANTIGENIC PEPTIDES; MAMMALIAN-CELLS; CTL EPITOPE; GENE GUN; MHC; AFFINITY; VACCINE; IMMUNOGENICITY; DETERMINANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Koide, Y Hamamatsu Univ, Sch Med, Dept Microbiol & Immunol, 3600 Handa Cho, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192 an
Citazione:
T. Yamada et al., "Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes arenoncompetitive", INFEC IMMUN, 69(5), 2001, pp. 3427-3430

Abstract

Taking advantage of the bet that plasmid DNA encoding a single cytotoxic Tlymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:31:19