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Titolo:
Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis
Autore:
Deepe, GS; Gibbons, R;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Med, Div Infect Dis, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ect Dis, Cincinnati, OH 45267 USA Cincinnati Vet Affairs Hosp, Cincinnati, OH USA Cincinnati Vet Affairs Hosp Cincinnati OH USA s Hosp, Cincinnati, OH USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 5, volume: 69, anno: 2001,
pagine: 3128 - 3134
SICI:
0019-9567(200105)69:5<3128:PEOHAF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL MEMORY; NECROSIS-FACTOR-ALPHA; IFN-GAMMA; INFECTION; IMMUNITY; MICE; REQUIREMENTS; VACCINES; ABSENCE; PLAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Deepe, GS Univ Cincinnati, Coll Med, Dept Med, Div Infect Dis, 231 Albert Sabin Way,Cincinnati, OH 45267 USA Univ Cincinnati 231 Albert Sabin Way Cincinnati OH USA 45267 USA
Citazione:
G.S. Deepe e R. Gibbons, "Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis", INFEC IMMUN, 69(5), 2001, pp. 3128-3134

Abstract

We previously reported that immunization with H antigen from Histoplasma capsulatum did not protect mice against an intravenous challenge with yeasts, Here, we investigated the utility of H antigen to protect mice in a modelof pulmonary histoplasmosis. Mice immunized with H antigen and challenged intranasally 4 weeks postvaccination were protected against sublethal and lethal challenges with H, capsulatum yeasts. If the challenge was performed 3 months after vaccination, there was a reduction in fungal burden following sublethal challenge and a modest delay in mortality in mice given a lethal inoculum, Vaccination was associated with production of gamma interferon,granulocyte-macrophage colony-stimulating factor, interleukin-4, and interleukin-10 by splenocytes. Vaccination with H antigen was not accompanied bya major expansion of CD4(+) or CD8(+) cells in spleens of mice. These results demonstrate that Il antigen may be useful as a protective immunogen against pulmonary exposure to H. capsulatum..

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:05:03