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Titolo:
T cell immunity in neonates
Autore:
Garcia, AM; Fadel, SA; Cao, S; Sarzotti, M;
Indirizzi:
Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Immunol, Durham, NC 27710 USA
Titolo Testata:
IMMUNOLOGIC RESEARCH
fascicolo: 2-3, volume: 22, anno: 2000,
pagine: 177 - 190
SICI:
0257-277X(2000)22:2-3<177:TCIIN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE LEUKEMIA-VIRUS; COLONY-STIMULATING FACTOR; WILD MOUSE RETROVIRUS; DENDRITIC CELLS; NEWBORN MICE; DNA IMMUNIZATION; ANTIGEN RECEPTOR; LYMPHOCYTE-RESPONSE; MEDIATED-IMMUNITY; HELPER CELL;
Keywords:
neonates; mouse; T lymphocytes; virus; cellular immunity; T cell repertoire; T cell priming; type 1/type 2 responses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, AM Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 pt Immunol, Durham, NC 27710 USA
Citazione:
A.M. Garcia et al., "T cell immunity in neonates", IMMUNOL RES, 22(2-3), 2000, pp. 177-190

Abstract

Typically, neonates exhibit decreased or aberrant cellular immune responses when compared to adults, resulting in increased susceptibility to infection. However, it is clear that newborns are able to generate adult-like protective T cell responses under certain conditions. The focus of our researchis to understand the deficiencies within the neonatal immune system that lead to improper cellular responses and how priming conditions can be altered to elicit the appropriate T cell response necessary to protect against development of pathogen-induced disease. With these goals in mind, we are exploring the attributes of neonatal T cells and their development, as well asthe conditions during priming that influence the resulting response to immune challenge during the neonatal period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:08:31