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Titolo:
Effect of bile acids on biliary excretion of cyclosporin A in the rat
Autore:
Takikawa, H; Sano, N; Takada, Y; Toda, A; Tanaka, H; Takamori, Y;
Indirizzi:
Teikyo Univ, Sch Med, Dept Med, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 t Med, Itabashi Ku, Tokyo 1738605, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 128 - 132
SICI:
1386-6346(200105)20:1<128:EOBAOB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
A-INDUCED CHOLESTASIS; HORSERADISH-PEROXIDASE; CANALICULAR MEMBRANE; HEPATOCYTE COUPLETS; LIVER; TAUROCHOLATE; TRANSPORT; PROTEIN; GENE; MRP2;
Keywords:
cyclosporin A; cholestasis; bile acids; P-glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Takikawa, H Teikyo Univ, Sch Med, Dept Med, Itabashi Ku, Kaga 2-11-1, Tokyo 1738605, Japan Teikyo Univ Kaga 2-11-1 Tokyo Japan 1738605 yo 1738605, Japan
Citazione:
H. Takikawa et al., "Effect of bile acids on biliary excretion of cyclosporin A in the rat", HEPATOL RES, 20(1), 2001, pp. 128-132

Abstract

Cyclosporin A, a substrate of P-glycoprotein (P-gp), is known to cause cholestasis in humans and in rat experimental models. Tauroursodeoxycholate isreported to be effective in CyA-induced cholestasis in rats. In the present study, to investigate the mechanism of the inhibition of CyA induced cholestasis, effect of bile acids on biliary cyclosporin A excretion was studied in rats, Infusion of both taurocholate and tauroursodeoxycholate at. the rate of 0.8 mmol/min per 100 g bodyweight increased bile flow and biliary cyclosporin A excretion, and the extent was more prominent with tauroursodeoxycholate. It was suggested that these findings were caused by the enhancedvesicular targeting of P-gp to the canalicular membrane by bile acids, thus increasing the numbers of P-gp in the canalicular membrane, (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:22:58