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Titolo:
Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma
Autore:
Kishimoto, Y; Morisawa, T; Kitano, M; Shiota, G; Horie, Y; Suou, T; Ito, H; Kawasaki, H; Hasegawa, J;
Indirizzi:
Tottori Univ, Fac Med, Dept Clin Pharmacol, Yonago, Tottori 6838503, JapanTottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan Tottori Univ, Fac Med, Dept Internal Med 2, Yonago, Tottori 6838503, JapanTottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan Tottori Univ Hosp, Dept Pathol, Yonago, Tottori 6838504, Japan Tottori Univ Hosp Yonago Tottori Japan 6838504 go, Tottori 6838504, Japan Tottori Univ, Fac Med, Dept Pathol 1, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 68 - 83
SICI:
1386-6346(200105)20:1<68:LOHOTM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; DINUCLEOTIDE REPEAT POLYMORPHISM; LIVER-CIRRHOSIS; M6P/IGF2R GENE; FACTOR-BETA; PATHOGENESIS; CELL; MUTATIONS; LOCUS; DNA;
Keywords:
hepatocellular carcinoma; liver cirrhosis; loss of heterozygosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kishimoto, Y Tottori Univ, Fac Med, Dept Clin Pharmacol, 86 Nishicho, Yonago, Tottori 6838503, Japan Tottori Univ 86 Nishicho Yonago Tottori Japan 6838503 , Japan
Citazione:
Y. Kishimoto et al., "Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma", HEPATOL RES, 20(1), 2001, pp. 68-83

Abstract

Information about M6P/IGF2R and p53 genes in hepatocarcinogenesis is limited and controversial. We tested the loss of heterozygosity (LOH) of M6P/IGF2R and p53 genes in cirrhotic and neoplastic foci in surgically resected livers of 30 patients with hepatocellular carcinoma (HCC). The DNAs extractedfrom microdissected specimens were used for polymerase-chain-reaction (PCR)-based assay. LOH of the M6P/IGF2R gene in the primary HCCs was detected in 10 of 22 informative cases (45%). In five of these 10 cases (50%), LOH was detected in cirrhotic lesions adjacent to the HCCs. The allelic loss patterns of M6P/IGF2R in liver cirrhosis (LC) were identical to those in the corresponding HCC, suggesting that HCC could develop from one of the cells inwhich M6P/IGF2R had been lost. Furthermore, LOH of the p53 gene in HCC wasdetected in 10 (43%) of 23 informative cases, and p53 loss in cirrhotic foci adjacent to HCC was shown in one of the 10 cases (10%). The pattern of allelic loss of the p53 gene in the cirrhotic foci was identical with that in the corresponding tumor. The LOH of the M6P/IGF2R and p53 genes occurred independently in HCCs. LOH of the M6P/IGF2R locus was a relatively frequentand possibly early event in hepatocarcinogenesis, and LOH of the M6P/IGF2Rgene and LOH of the p53 gene occurred independently. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:46:28