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Titolo:
Correlation between p21(waf1) and p16(INK4 alpha) expression in hepatocellular carcinoma
Autore:
Fukushima, K; Ueno, Y; Yamagiwa, Y; Yamakawa, M; Iwasaki, T; Ishii, M; Toyota, T; Shimosegawa, T;
Indirizzi:
Tohoku Univ, Sch Med, Dept Internal Med 3, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 52 - 67
SICI:
1386-6346(200105)20:1<52:CBPAPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; HUMAN CANCERS; DNA METHYLTRANSFERASE; P16(INK4A) GENE; P53; METHYLATION; INACTIVATION; INHIBITOR; TISSUES; ISLAND;
Keywords:
HCC; CDK; methylation; p73; p53; p63;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ueno, Y Tohoku Univ, Sch Med, Dept Gastroenterol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai MiyagiJapan 9808574 74, Japan
Citazione:
K. Fukushima et al., "Correlation between p21(waf1) and p16(INK4 alpha) expression in hepatocellular carcinoma", HEPATOL RES, 20(1), 2001, pp. 52-67

Abstract

Background: The cyclin dependent kinase p21(waf1) plays a crucial role in the regulation of cell cycle. The family of p53 proteins has the ability toinduce p21(waf1), whereas p16(INK4 alpha) modulates post-transcriptionallythe expression of p21(waf1). Methods: Total 36 hepatocellular carcinomas (HCCs) and 24 paired adjacent liver tissues were evaluated for the following: (1) expression of p21(waf1) and p16(INK4 alpha); (2) that of p21(waf1), p73 and p63 mRNAs; (3) genomic mutations and the loss of heterozygosity of p73 and p53; and (4) frequency of methylation in the 5'CpG promoter region of p16(INK4 alpha). Results: In HCCs compared with the adjacent non-cancerous liver tissues, the expression of p21(waf1) and p16(INK4 alpha) was reduced. Indeed, p21(waf1) was not detected in 36% (8/22) of HCCs in spite of thepresence of p21(waf1) mRNA: among them, mutations of p53 gene were found in 50%, whereas a lack of p16(INK4 alpha) expression in all of them. p21(waf1) and p16(INK4 alpha) were reduced in proportion to the degree of methylation in p16(INK4 alpha) gene, p73 did not mutated, and p63 did not expressedin HCCs. Conclusion: Methylation status of p16(INK4 alpha) gene will play a part for reducing constitutive expression of p16(INK4 alpha) and of p21(waf1) coordinately in HCCs. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:24:34