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Titolo:
Clinical usefulness of the branched DNA assay version 2 in predicting the efficacy of Interferon treatment in a group of chronic HCV patients based on serotype
Autore:
Mahmood, S; Nakata, K; Sho, M; Kimura, T; Manabe, Y; Kinoyama, S; Ito, T; Yamada, G;
Indirizzi:
Kawasaki Hosp, Kawasaki Med Sch, Ctr Liver Dis, Dept Clin Res & Internal Med, Okayama 7008505, Japan Kawasaki Hosp Okayama Japan 7008505 Internal Med, Okayama 7008505, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 9 - 17
SICI:
1386-6346(200105)20:1<9:CUOTBD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; POLYMERASE-CHAIN-REACTION; LONG-TERM RESPONSE; ALPHA THERAPY; QUANTITATIVE ASSAYS; RNA; INFECTION; SERUM; LOAD; QUANTIFICATION;
Keywords:
interferon; viral load; serotype; bDNA assay; complete response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Mahmood, S Kawasaki Hosp, Kawasaki Med Sch, Ctr Liver Dis, Dept Clin Res &Internal Med, 2-1-80 Nakasange, Okayama 7008505, Japan Kawasaki Hosp 2-1-80 Nakasange Okayama Japan 7008505 05, Japan
Citazione:
S. Mahmood et al., "Clinical usefulness of the branched DNA assay version 2 in predicting the efficacy of Interferon treatment in a group of chronic HCV patients based on serotype", HEPATOL RES, 20(1), 2001, pp. 9-17

Abstract

Interferon (IFN) response depends upon pretreatment viral loads and viral genotype/serotype. This study investigated the difference in response to IFN in different viral load groups of 96 chronic hepatitis C patients and compared version 1 (bDNA1.0) and version 2 (bDNA2.0) of the branched DNA assay, according to serotype. On univariate analysis, viral load (P = 0.0001, bybDNA 1.0; P = 0.0020, by bDNA 2.0,), serotype (P = 0.0053) and age (P = 0.0073) were significant predictors of IFN response. On multivariate analysis, serotype (odds ratio, 5.44; 95% confidence interval, 1.94-15.24; P < 0.01) was a stronger predictor of IFN response than age or viral load (by bDNA2.0). In very high (<greater than> 6.7 log eq/ml), high (6.0 similar to 6.69log eq/ml) and low (< 6 log eq/ml) viral load groups (by bDNA2.0), complete response was 25, 55 and 92.6% in serotype 2 (sero-2), and 10, 20 and 71.4% in serotype 1 (sero-l), respectively. In sero-2, bDNA2.0 can detect high viral loads underestimated by bDNA1.0. In a low viral load group (by bDNA2.0), IFN response is dependent upon serotype; sero-2 responded better than sere-1. However, in high and very high viral load groups, sensitivities of bDNA1.0 and bDNA2.0 are not effective in clinically distinguishing CR from non-response, and aid in patient selection for IFN therapy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:23:54