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Titolo:
Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family
Autore:
Vidal, R; Calero, M; Revesz, T; Plant, G; Ghiso, J; Frangione, B;
Indirizzi:
NYU, Sch Med, Dept Pathol, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Pathol, New York, NY USA Inst Neurol, Dept Neuropathol, London, England Inst Neurol London England st Neurol, Dept Neuropathol, London, England Natl Hosp Neurol & Neurosurg, London, England Natl Hosp Neurol & Neurosurg London England Neurosurg, London, England
Titolo Testata:
GENE
fascicolo: 1-2, volume: 266, anno: 2001,
pagine: 95 - 102
SICI:
0378-1119(20010321)266:1-2<95:SGSATE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; BRITISH DEMENTIA; SECRETASE ACTIVITY; PROMOTER; REGION; DIFFERENTIATION; TRANSCRIPTION; PRESENILIN-1; CONSERVATION;
Keywords:
FED; FDD; ABri; Alzheimers; amyloid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Vidal, R Indiana Univ, Sch Med, Dept Pathol & Lab Med, 636 Barnhill Dr,MS A133, Indianapolis, IN 46202 USA Indiana Univ 636 Barnhill Dr,MS A133 Indianapolis IN USA 46202 SA
Citazione:
R. Vidal et al., "Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family", GENE, 266(1-2), 2001, pp. 95-102

Abstract

The BRI3 gene is a member of the BRI gene family, made up of at least three different genes (BRI1-3) Previous studies established the cDNA sequence and structure of the human and mouse BRI1 and BRI2 genes and we recently reported that mutations in the BRI2 isoform, located on chromosome 13, are associated with dementia in humans. In the present work. we determine the complete cDNA sequence and genomic organization of the human BRI3 gene. BRI3 codes for a polypeptide of 267 amino acids, with a Mr of 30 KDa and a pi of 8.47. The amino acid sequence is 43.7% identical to the sequence of the human BRI2, and 38.3% identical to that of human BRII, with the highest percentage of amino acid identity bring concentrated on the C-terminal half of themolecules. In Northern blots, BRI3 cDNA hybridizes only one message of approximately 2.1 kilobases, which is predominantly present in the human brain. The BRI3 gene is localized on chromosome 2 and consists of six exons spanning more than 20 kb. Homology search of EST data banks retrieved a Caenorhubditis briggsae homolog of BRI, indicating that the BRI gene belongs to a strongly conserved gene family. These studies, aimed at characterizing the members of the BRI gene family, may provide valuable clues to the understanding of their normal function and how mutations in BRII can cause neurodegeneration and dementia similar to Alzheimer's disease. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:19:51