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Titolo:
The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins
Autore:
Charlab, R; Valenzuela, JG; Andersen, J; Ribeiro, JMC;
Indirizzi:
NIAID, Sect Med Entomol, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
GENE
fascicolo: 1, volume: 267, anno: 2001,
pagine: 13 - 22
SICI:
0378-1119(20010404)267:1<13:TIGFSO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLY LUTZOMYIA-LONGIPALPIS; MOSQUITO ANOPHELES-ALBIMANUS; SALIVARY-GLANDS; MAST-CELLS; PURIFICATION; CLONING; NOCICEPTION; RECEPTORS; MOLSCRIPT; ANALOGS;
Keywords:
gene family; pfam domain; sand fly; salivary gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, JMC NIAID, Sect Med Entomol, Parasit Dis Lab, NIH, 4 Ctr Dr,Bldg 4-126, Bethesda, MD 20892 USA NIAID 4 Ctr Dr,Bldg 4-126 Bethesda MD USA 20892 MD 20892 USA
Citazione:
R. Charlab et al., "The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins", GENE, 267(1), 2001, pp. 13-22

Abstract

Adenosine deaminase (ADA) catalyzes the hydrolysis of adenosine to inosine. Its lack determines severe combined immunodeficiency in mammals, possiblydue to accumulation of extracellular adenosine, which induces apoptosis inlymphocytes (Franco et al., 1998). Thus, presence of normal levels of ADA leads to normal growth and proliferation of lymphocytes. Several vertebrateand microbial ADA aminoacid sequences are known, with substantial similarity to each other. On the other hand, there are invertebrate growth factors as well as a candidate gene for the human cat eye syndrome (CECR1) (Riazi et al., 2000. Genomics 64, 277-285), which share substantial similarity to each other, and also to ADA. In this study, we report the expression and ADAenzymatic activity of a cDNA from the salivary glands of Lutzomyia longipalpis, a blood-sucking insect, with substantial similarity to insect growth factors and to human CECR1. We also demonstrate the existence of a subfamily of the adenosine deaminase family characterized by their unique amino-terminal region. Both Drosophila melanogaster and humans have both types of adenosine deaminases. Results indicate that these invertebrate proteins previously annotated as growth factors, as well as the human CECR1 gene product,may exert their actions through adenosine depletion. The different roles played by each type of adenosine deaminase in humans and Drosophila remains to be fully investigated. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:24:58