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Titolo:
Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic,noncholinergic mechanism
Autore:
Vemulapalli, S; Kurowski, S;
Indirizzi:
Schering Plough Res Inst, CNS, CV Biol Res, Kenilworth, NJ 07033 USA Schering Plough Res Inst Kenilworth NJ USA 07033 Kenilworth, NJ 07033 USA
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 1 - 7
SICI:
0767-3981(200102)15:1<1:PMRRCC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE YOHIMBINE HYDROCHLORIDE; MALE ERECTILE DYSFUNCTION; NITRIC-OXIDE; SMOOTH-MUSCLE; SILDENAFIL; IMPOTENCE; RELAXATION; MEDIATOR;
Keywords:
electrical field stimulation; L-Name; Nitric oxide; phentolamine mesylate; rabbit corpus cavernosum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Vemulapalli, S Schering Plough Res Inst, CNS, CV Biol Res, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Res Inst 2015 Galloping Hill Rd Kenilworth NJ USA 07033
Citazione:
S. Vemulapalli e S. Kurowski, "Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic,noncholinergic mechanism", FUN CL PHAR, 15(1), 2001, pp. 1-7

Abstract

The contribution of NO-cGMP dependent pathway to phentolamine mesylate-evoked nonadrenergic, noncholinergic relaxation of rabbit corpus cavernosum was investigated in vitro, Stimulation of nonadrenergic, noncholinergic neurons of the rabbit corpus cavernosum elicited frequency-related relaxation that was significantly attenuated by L-NAME (NO synthase inhibitor) or ODQ tan inhibitor of guanylate cyclase), Moreover, tetrodotoxin, a sodium channelblocker, abolished the electrical field stimulation-induced relaxation of rabbit corpus cavernosum suggesting that neuronal release of NO mediates relaxation to electrical field stimulation. Phentolamine mesylate (30 and 100nM) dose-dependently enhanced electrical field stimulation-induced relaxation of the rabbit corpus cavernosum. Prazosin (30 muM) and yohimbine (30 muM) failed to affect phentolamine mesylate-mediated nonadrenergic, noncholinergic rabbit penile smooth muscle relaxation, suggesting that phentolamine relaxes rabbit corpus cavernosum independent of a-adrenergic receptor blockade. In contrast, pretreatment of the rabbit cavernosal strips with L-NAME significantly-attenuated electrical field stimulation produced relaxations to phentolamine mesylate, suggesting that phentolamine mesylate relaxes rabbit corpus cavernosum by activating NO synthase, The data suggest that phentolamine mesylate relaxes nonadrenergic noncholinergic neurons of the rabbit corpus cavernosum by activating NO synthase and is independent of cr-adrenergic receptor blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:29:10