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Titolo:
Retinol supplementation induces oxidative stress and modulates antioxidantenzyme activities in rat sertoli cells
Autore:
Dal-Pizzol, F; Klamt, F; Benfato, MS; Bernard, EA; Moreira, JCF;
Indirizzi:
Univ Fed Rio Grande Sul, ICBS, Dept Bioquim, Lab Estresse Oxidat, BR-90035003 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90035003 BC, RS, Brazil Univ Fed Rio Grande Sul, Dept Biofis, BR-90035003 Porto Alegre, RS, BrazilUniv Fed Rio Grande Sul Porto Alegre RS Brazil BR-90035003 BC, RS, Brazil
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 4, volume: 34, anno: 2001,
pagine: 395 - 404
SICI:
1071-5762(2001)34:4<395:RSIOSA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-A; DNA-DAMAGE; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; MAMMALIAN-CELLS; BETA-CAROTENE; LUNG-CANCER; DIET; CARCINOMA; CATALASE;
Keywords:
retinol; oxidative stress; reactive oxygen species; lipid peroxidation; catalase; glutathione peroxidase; superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Moreira, JCF Univ Fed Rio Grande Sul, ICBS, Dept Bioquim, Lab Estresse Oxidat, Ramiro Barcelos 2600, BR-90035003 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Ramiro Barcelos 2600 Porto Alegre RS Brazil BR-90035003 BC
Citazione:
F. Dal-Pizzol et al., "Retinol supplementation induces oxidative stress and modulates antioxidantenzyme activities in rat sertoli cells", FREE RAD RE, 34(4), 2001, pp. 395-404

Abstract

Recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer. Recently the causal mechanismhas begun to be clarified. We report here that retinol caused cellular oxidative stress and modulated superoxide dismutase, catalase and glutathione peroxidase activities. Retinol (7 muM) significantly increased TBARS, conjugated dienes, and hydroperoxide-initiated chemiluminescence in cultured Sertoli cells. In response to retinol treatment superoxide dismutase, catalaseand glutathione peroxidase activities increased. TBARS content and catalase activities were decreased by a free radical scavenger. These findings suggest that retinol may induce oxidative stress and modulate antioxidant enzyme activities in Sertoli cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 09:22:24