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Titolo:
Effect of obesity and troglitazone on expression of two glutathione peroxidases: Cellular and extracellular types in serum, kidney and adipose tissue
Autore:
Asayama, K; Nakane, T; Dobashi, K; Kodera, K; Hayashibe, H; Uchida, N; Nakazawa, S;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Yamanashi Med Univ, Dept Pediat, Tamaho, Yamanashi 4093898, Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 4, volume: 34, anno: 2001,
pagine: 337 - 347
SICI:
1071-5762(2001)34:4<337:EOOATO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATOR-ACTIVATED RECEPTORS; INDUCED DIABETIC RATS; PEROXISOME PROLIFERATOR; PPAR-GAMMA; DIFFERENTIAL EXPRESSION; NIDDM PATIENTS; MESSENGER-RNA; HUMAN-PLASMA; ZUCKER RATS; SELENIUM;
Keywords:
glutathione peroxidase; gene expression; adipose tissue; free radicals; obesity; peroxisome proliferator-activated receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Asayama, K Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, YahatanishiKu, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth 1-1 Iseigaoka Kitakyushu Fukuoka Japan 8078555
Citazione:
K. Asayama et al., "Effect of obesity and troglitazone on expression of two glutathione peroxidases: Cellular and extracellular types in serum, kidney and adipose tissue", FREE RAD RE, 34(4), 2001, pp. 337-347

Abstract

To determine the effect of obesity on expression of cellular- (C-) and extracellular (EC-) glutathione peroxidase (GPX) in serum, kidney and adipose tissue, we measured GPX in serum, kidneys and adipose tissue of the obese Otsuka-Long-Evans-Tokushima Fatty (OLETF) rat and its lean counterpart (LETO). We also investigated the effect of troglitazone. Five each of OLETF and LETO rats were fed diet with or without 0.2% troglitazone for 10 days. Final body weight, kidney weight, blood glucose and serum tumor necrosis factor-alpha (TNF-alpha) level were higher in OLETF rats than in LETO rats. Serumand kidney GPX activities were higher, but adipose tissue GPX activity waslower, in OLETF rats than in LETO rats. Troglitazone treatment decreased adipose tissue GPX activity and abolished overproduction of TNF-alpha in OLETF rats. Immunoblot analysis, for the first time, revealed that both obesity and troglitazone suppressed the protein signals for C-GPX and EC-GPX in adipose tissue. Serum protein carbonyl groups were increased in OLETF rats and troglitazone completely blocked this increase. increased serum GPX activity in obese rat was due to the increased secretion of EC-GPX from the kidney. Troglitazone protected against the enhanced oxidative stress induced byobesity independently of the serum GPX concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:38:09