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Titolo:
Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
Autore:
Hashimoto, G; Aoki, T; Nakamura, H; Tanzawa, K; Okada, Y;
Indirizzi:
Keio Univ, Sch Med, Dept Pathol, Shinjuku Ku, Tokyo 160016, Japan Keio Univ Tokyo Japan 160016 pt Pathol, Shinjuku Ku, Tokyo 160016, Japan Sumitomo Pharmaceut Co Ltd, Div Res, Konohana Ku, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd Osaka Japan 5540022 Ku, Osaka 5540022, Japan Fuji Chem Ind Ltd, Dept Biopharmaceut, Toyama 9338511, Japan Fuji Chem IndLtd Toyama Japan 9338511 pharmaceut, Toyama 9338511, Japan Sankyo Co Ltd, Biol Res Labs, Shinagawa Ku, Tokyo 1408710, Japan Sankyo CoLtd Tokyo Japan 1408710 bs, Shinagawa Ku, Tokyo 1408710, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 494, anno: 2001,
pagine: 192 - 195
SICI:
0014-5793(20010413)494:3<192:IOA(BT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM PENTOSAN POLYSULFATE; HUMAN SYNOVIAL-FLUID; MATRIX METALLOPROTEINASES; ARTICULAR-CARTILAGE; FRAGMENTS; FAMILY; OSTEOARTHRITIS; FERTILIZATION; DISINTEGRIN; GENERATION;
Keywords:
tissue inhibitor of metalloproteinases; A disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; aggrecanase; aggrecan degradation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, Y Keio Univ, Sch Med, Dept Pathol, Shinjuku Ku, 35 Shinano Machi, Tokyo 160016, Japan Keio Univ 35 Shinano Machi Tokyo Japan 160016 okyo 160016, Japan
Citazione:
G. Hashimoto et al., "Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)", FEBS LETTER, 494(3), 2001, pp. 192-195

Abstract

ADAMTS4 (aggrecanase-1) is considered to play. a key role in the degradation of aggrecan in arthritides, The inhibitory activity of tissue inhibitorsof metalloproteinases (TIMPs) to ADAMTS4 was examined in an assay using aggrecan substrate. Among the four TIMPs, TIMP-3 inhibited the activity most efficiently with an IC50 value of 7.9 nM, which was at least 44-fold lower than that of TIMP-1 (350 nM) acid TIMP-2 (420 nM) and > 250-fold less than that of TIMP-4 (2 muM for 35% inhibition). These results suggest that TIMP-3 is a potent inhibitor against the aggrecanase activity of ADAMTS4 in vivo. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:24:05