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Titolo:
Effects of epidermal growth factor in artificial tear on vitamin C levels of corneal wounded eye tissues
Autore:
Gonul, G; Kaplan, B; Bilgihan, K; Budak, MT;
Indirizzi:
Gazi Univ, Fac Med, Dept Physiol, TR-06500 Ankara, Turkey Gazi Univ Ankara Turkey TR-06500 , Dept Physiol, TR-06500 Ankara, Turkey Gazi Univ, Fac Med, Dept Ophthalmol, TR-06500 Ankara, Turkey Gazi Univ Ankara Turkey TR-06500 ept Ophthalmol, TR-06500 Ankara, Turkey
Titolo Testata:
EYE
, volume: 15, anno: 2001,
parte:, 2
pagine: 213 - 216
SICI:
0950-222X(200104)15:<213:EOEGFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCORBIC-ACID; AQUEOUS-HUMOR; DOSAGE FORMS; GUINEA-PIG; EGF; MICE; COLLAGEN; STRENGTH; BETA;
Keywords:
aqueous humour; artificial tears; ascorbic acid; corneal wound healing; EGF; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gonul, G Gazi Univ, Fac Med, Dept Physiol, TR-06500 Ankara, Turkey Gazi Univ Ankara Turkey TR-06500 ysiol, TR-06500 Ankara, Turkey
Citazione:
G. Gonul et al., "Effects of epidermal growth factor in artificial tear on vitamin C levels of corneal wounded eye tissues", EYE, 15, 2001, pp. 213-216

Abstract

Purpose To investigate the effect of artificial tear (AT) solution and epidermal growth factor (EGF) treatment on the cornea and aqueous humour ascorbic acid (AA) levels of full-thickness conceal wounded eyes. Methods The effect of EGF on the AA levels of aqueous humour and conceal wound tissue was determined in full-thickness conceal wounded rabbit eyes onthe seventh postoperative day. There were three groups: untreated controls, AT-treated controls and an EGF+AT-treated experimental group (n = 6 in each group). Conceal wounded eyes were topically treated with 5 mul AT or 5 mul EGF in AT (1 mg/l EGF in AT prepaaration which contained 3.0% carbopol 940) twice daily for 6 days after operation. The wound strengths were also measured on the seventh postoperative day as a measure of wound healing. Statistical analysis was carried out using the Mann-Whitney U-test by Statviewprogram. Results The wound strengths of corneas, and AA levels of wound tissues andaqueous humour, increased significantly following AT and EGF treatment (p < 0.05). Conclusion In the conceal wounded eye, aqueous humour serves as a source of vitamin C and there may be a relation between EGF treatment in AT and AA levels of corneal wounded eye tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:55:33