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Titolo:
In vitro migratory responses of swine neutrophils to Actinobacillus pleuropneumoniae
Autore:
Wang, FI; Yang, JWJ; Hung, SY; Pan, IJ;
Indirizzi:
Natl Taiwan Univ, Dept Vet Med, Taipei 106, Taiwan Natl Taiwan Univ Taipei Taiwan 106 niv, Dept Vet Med, Taipei 106, Taiwan Nihon Univ, Lab Vet Epizootiol, Fujisawa, Kanagawa 2528510, Japan Nihon Univ Fujisawa Kanagawa Japan 2528510 isawa, Kanagawa 2528510, Japan
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 2, volume: 50, anno: 2001,
pagine: 139 - 145
SICI:
1341-1357(200104)50:2<139:IVMROS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALVEOLAR MACROPHAGES; PSEUDORABIES VIRUS; PORCINE; CELLS; LEUKOCYTES; CHEMOTAXIS; INFECTION; CHEMILUMINESCENCE; PATHOGENESIS; EXPRESSION;
Keywords:
Actinobacillus pleuropneumoniae; chemotaxis; neutrophil; pseudorabies virus; swine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, FI Natl Taiwan Univ, Dept Vet Med, 142 Chou San Rd, Taipei 106, Taiwan Natl Taiwan Univ 142 Chou San Rd Taipei Taiwan 106 i 106, Taiwan
Citazione:
F.I. Wang et al., "In vitro migratory responses of swine neutrophils to Actinobacillus pleuropneumoniae", EXP ANIM, 50(2), 2001, pp. 139-145

Abstract

Swine neutrophils were quantitatively examined for the direct and indirectmigratory responses to Actinobacillus pleuropneumoniae (APP) in vitro and the effects of pseudorabies virus (PrV), frequently co-infecting with APP, were also observed. About 30% of swine neutrophils responded to viable APP,while 3.2% of the neutrophils responded to 0.1% casein which served as thecontrol. The migration to APP was not affected by preincubation of neutrophils with PrV, which inhibited the random migration. When the random migration was normalized to 1, the chemotactic indices for APP, opsonized-APP andcasein were 64, 70 and 8.5, respectively Heat-killed APP or E. coli lipopolysaccharide stimulated the production of interleukin-8 activity by adherent peripheral blood mononuclear cells (PBMC). Preincubation of PBMC with PrVinhibited the production of neutrophil attractant activity when stimulatedwith heat-killed APP. The results suggested that the direct chemotaxis of neutrophils to viable APP might contribute to early infiltration in Actinobacillus pleuropneumonia, and that PrV might inhibit indirect recruitment ofneutrophils to infected lungs by compromising the functions of PBMC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:29:14