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Titolo:
Vascular smooth muscle cell phenotypes in primary pulmonary hypertension
Autore:
Mitani, Y; Ueda, M; Komatsu, R; Maruyama, K; Nagai, R; Matsumura, M; Sakurai, M;
Indirizzi:
Osaka City Univ, Sch Med, Dept Pathol, Abeno Ku, Osaka 545, Japan Osaka City Univ Osaka Japan 545 Dept Pathol, Abeno Ku, Osaka 545, Japan Mie Univ, Sch Med, Dept Pediat, Tsu, Mie 514, Japan Mie Univ Tsu Mie Japan 514 niv, Sch Med, Dept Pediat, Tsu, Mie 514, Japan Mie Univ, Sch Med, Dept Anesthesiol, Tsu, Mie 514, Japan Mie Univ Tsu MieJapan 514 Sch Med, Dept Anesthesiol, Tsu, Mie 514, Japan Gunma Univ, Sch Med, Dept Med 2, Maebashi, Gumma 371, Japan Gunma Univ Maebashi Gumma Japan 371 ept Med 2, Maebashi, Gumma 371, Japan Tenri Hosp, Dept Pediat, Tenri, Nara 632, Japan Tenri Hosp Tenri Nara Japan 632 Hosp, Dept Pediat, Tenri, Nara 632, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 17, anno: 2001,
pagine: 316 - 320
SICI:
0903-1936(200102)17:2<316:VSMCPI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY ANGIOPLASTY; EXPRESSION;
Keywords:
cytoskeletal proteins; fibronectin; intimal hyperplasia; macrophage; plexiform lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, M Osaka City Univ, Sch Med, Dept Pathol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 545, Japan Osaka City Univ 1-4-3 Asahi Machi Osaka Japan 545 saka 545, Japan
Citazione:
Y. Mitani et al., "Vascular smooth muscle cell phenotypes in primary pulmonary hypertension", EUR RESP J, 17(2), 2001, pp. 316-320

Abstract

Primary pulmonary hypertension (PPH) is associated with specific structural alterations, including cellular intimal thickening, intimal fibrosis, andplexiform lesions,To determine the phenotypes of smooth muscle cells (SMCs) in such lesions,the authors conducted an immunohistochemical analysis of lung tissues fromtwo patients with PPH, using two antimuscle actin antibodies, MF35 and CGA7, and two anti-SMC myosin heavy chain markers, anti-SM1 and anti-SM2 antibodies and related antibodies. Cells that stained positive (+) with HHF35, CGA7, anti-SM1, and anti-SM2 were considered to be SMCs of a mature state. Conversely, those that stained positive with HHF35 and anti-SM1, but weakly positive (+/-) or negative (-) with CGA7 and anti-SM2, were considered to be SMCs exhibiting an immature state. Cellular intimal thickening mas composed of SMCs of an immature phenotype (HHF35+, CGA7+/-, SM1+, SM2+/-), accompanied by the expression of fibronectin and the presence of macrophages; intimal fibrosis contained mature SMCs (HHF35+, CGA7+, SM1+, SM2+); and plexiform lesion consisted of proliferative endothelial cells (von Willebrand factor-positive cells, proliferating cell nuclear antigen-positive tells) and underlying immature SMCs (HHF35+, CGA7-, SM1+, SM2-) associated with fibronectin expression and macrophage infiltration. These findings suggest that smooth muscle cells with specific phenotypes mag contribute to the development of specific vascular lesions in primary pulmonary hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 18:58:24