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Titolo:
Histamine challenges discriminate between symptomatic and asymptomatic children
Autore:
Niggemann, B; Illi, S; Madloch, C; Volkel, K; Lau, S; Bergmann, R; von Mutius, E; Wahn, U;
Indirizzi:
Humboldt Univ, Childrens Hosp Charite, Dept Pediat Pneumol & Immunol, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 & Immunol, D-13353 Berlin, Germany Univ Childrens Hosp, Munich, Germany Univ Childrens Hosp Munich GermanyUniv Childrens Hosp, Munich, Germany
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 17, anno: 2001,
pagine: 246 - 253
SICI:
0903-1936(200102)17:2<246:HCDBSA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; AIRWAY HYPERRESPONSIVENESS; RESPIRATORY SYMPTOMS; ASTHMATIC-CHILDREN; NORMAL INFANTS; LUNG-FUNCTION; RISK-FACTORS; AUSTRALIAN SCHOOLCHILDREN; METHACHOLINE CHALLENGES; PULMONARY-FUNCTION;
Keywords:
asthma; bronchial hyperresponsiveness; children; cut-off value; histamine challenge; PC20FEV1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Niggemann, B Humboldt Univ, Childrens Hosp Charite, Dept Pediat Pneumol & Immunol, Augustenburger Pl 1, D-13353 Berlin, Germany Humboldt Univ Augustenburger Pl 1 Berlin Germany D-13353 any
Citazione:
B. Niggemann et al., "Histamine challenges discriminate between symptomatic and asymptomatic children", EUR RESP J, 17(2), 2001, pp. 246-253

Abstract

The aims of this study were to investigate a threshold value for branchialresponsiveness in children aged 7 yrs, which discriminates between symptomatic and asymptomatic children, and to identify determinants of this responsiveness. Titrated branchial histamine challenges using the reservoir method were performed in 645 children aged 7 yrs, from the birth cohort Multicentre Allergy Study (MAS). When defining a reference population of healthy children within the MAS cohort? the 95th percentile of the provocative concentration causing a 20% fail in forced expired volume in one second PC20 among these asymptomatic study subjects amounted to 0.60 mg.mL(-1) This resulted in a specificity of 93.0% and a sensitivity of 45.9%, for discriminating between "current wheezers" and "non-current wheezers". Determinants of airway responsiveness at this age were pulmonary function, sensitization to indoor allergens, total immunoglobulin E and current wheeze,The results indicate that a very low cut-off provocative concentration causing a 20% fall in forced expired volume in one second (<1.0 mg.mL(-1)) defines airway hyperresponsiveness in children aged 7 yrs using the reservoir method. Provocation protocols far histamine challenges in this age group should therefore start with concentrations markedly below 1.0 mg.mL(-1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 08:47:10