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Titolo:
Five-year results of elastin and collagen markers as predictive tools in the management of small abdominal aortic aneurysms
Autore:
Lindholt, JS; Heickendorff, L; Vammen, S; Fasting, H; Henneberg, EW;
Indirizzi:
Viborg Hosp, Dept Vasc Surg, Viborg, Denmark Viborg Hosp Viborg DenmarkViborg Hosp, Dept Vasc Surg, Viborg, Denmark Aarhus Univ, Amtssygehuset, Dept Clin Biochem, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C ept Clin Biochem, DK-8000 Aarhus C, Denmark
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 235 - 240
SICI:
1078-5884(200103)21:3<235:FROEAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE MANAGEMENT; DIAMETER;
Keywords:
abdominal aortic aneurysm; natural history; expansion; mass screening; surveillance; elastin peptides; surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lindholt, JS Laerkevej 11, DK-8900 Randers, Denmark Laerkevej 11 RandersDenmark DK-8900 -8900 Randers, Denmark
Citazione:
J.S. Lindholt et al., "Five-year results of elastin and collagen markers as predictive tools in the management of small abdominal aortic aneurysms", EUR J VAS E, 21(3), 2001, pp. 235-240

Abstract

Objective: small abdominal aortic aneurysms (AAAs) do rupture and on;y half of AAAs above 5 cm would have ruptured unoperated. Furthermore, conservative treatment of AAAs may cause psychological side effects and impaired quality of life. To optimise the indication and time for operation for AAAs, we analysed whether serum elastin peptides (EP), procollagen-IIIN-terminal propeptide (PIIINP), and the initial AAA size could predict operation for AAAs in initially conservatively treated AAA. Material and Methods: in 1994, 4404 65-73 year old males were invited to hospital-based screening for AAAs by ultrasonography. Seventy-six percent attended. One hundred and forty-one (4.2%) had AAAs (def: +30 mm). Nineteen were offered operation (AAA + 50 mm), and 112 were followed with annual control scans for 1-5 years (mean 2.5 years). Of these, 99 had their EP (ng/ml)and PIIINP (ng/ml) determined using ELISA and RIA techniques. Two observers and one scanner were used. Results: the mean expansion rate was 2.7 mm/year. The initial AAA size (r = 0.46; 0.26-0.61), EP (r = 0.31; 0.11-0.19), and NIIIP (r = 0.24; 0.02-0.44) was independently significant associated to expansion rate in a multiplelinear regression analysis including the three mentioned variables. The multivariate formula could by ROC curve analysis predict cases reaching 5 cm in diameter within 5 years with a sensitivity and specificity of 91% and 87%, respectively, increasing to 91% and 94% respectively, by accepting a 2 mm variation in those measurements. Twenty-three were lost to follow up, 21 of these due to death or severe illness. Of these, seven would have been predicted to reach an AAA size recommendable for surgery. If all 23 were included in the analysis, the specificity would have been 87% and 85%, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:46:29