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Titolo:
Increased acute phase reactants are associated with levels of lipoproteinsand increased carotid plaque volume
Autore:
Gronholdt, MLM; Sillesen, H; Wiebe, BM; Laursen, H; Nordestgaard, BG;
Indirizzi:
Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp, Gentofte Hosp, Dept Vasc Surg, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Neuropathol Lab, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp, Herlev Hosp, Dept Clin Biochem, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O DK-2100 Copenhagen O, Denmark
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 227 - 234
SICI:
1078-5884(200103)21:3<227:IAPRAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; CORONARY-ARTERY DISEASE; GENE-EXPRESSION; HEART-DISEASE; ATHEROSCLEROSIS; TRIGLYCERIDE; RICH; ATHEROGENESIS; INTERLEUKIN-6;
Keywords:
arteriosclerosis; acute phase reactants; carotid disease; ultrasonics; lipoproteins; pathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gronholdt, MLM Univ Copenhagen Hosp, Rigshosp, Dept Vasc Surg, RK 3112,Blegdamsvej 9, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp RK 3112,Blegdamsvej 9 Copenhagen Denmark O
Citazione:
M.L.M. Gronholdt et al., "Increased acute phase reactants are associated with levels of lipoproteinsand increased carotid plaque volume", EUR J VAS E, 21(3), 2001, pp. 227-234

Abstract

Objectives: to test the hypotheses that increased acute phase reactants plpredict elevated levels of lipoproteins and increased plaque volume as well as echolucency of carotid plaques. Materials and Methods: the study included 258 patients with greater than or equal to 50% carotid artery stenosis. Acute phase reactants (orosomucoid,C-reactive protein (CRP)) were measured in the fasting state, and ultracentrifugated lipoproteins before and after a standardised fat load test. Echogenicity of carotid plaques was detected using high-resolution B-mode ultrasound and computer-assisted image processing. A subgroup of 81 patients underwent carotid endarterectomy. Results: on linear regression analysis orosomucoid levels were positively associated with fasting and postprandial levels of all triglyceride-rich lipoproteins, and negatively associated with HDL cholesterol (p-values <0.001); results for CRP were less pronounced. Orosomucoid and CRP both predictedthe presence of an increased carotid plaque volume on univariate analysis (p = 0.01 and p = 0.02). Finally, orosomucoid was negatively associated with echolucency of carotid plaques ( p = 0.05). Conclusions: elevated levels of acute phase reactants are strongly associated with elevated levels of triglyceride-rich lipoproteins, increased plaque volume, and borderline significantly associated with echolucency of carotid plaques. Elevated acute phase reactants possibly predict severity of atherosclerosis, and presence of lipid-rich, rupture-prone plaques.

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Documento generato il 29/09/20 alle ore 09:55:50