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Titolo:
Induction of oral tolerance to cellular immune responses in the absence ofPeyer's patches
Autore:
Spahn, TW; Fontana, A; Faria, AMC; Slavin, AJ; Eugster, HP; Zhang, XM; Koni, PA; Ruddle, NH; Flavell, RA; Rennert, PD; Weiner, HL;
Indirizzi:
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 eurol Dis, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Univ Zurich Hosp, Dept Internal Med, Clin Immunol Sect, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Hughes Med Inst, New Haven, CT 06510 USA Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Immunobiol Sect, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 iol & Publ Hlth, New Haven, CT 06510 USA Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Immunobiol Sect, New Haven, CT 06510 USA Biogen, Cambridge Ctr 12, Cambridge, MA USA Biogen Cambridge MA USABiogen, Cambridge Ctr 12, Cambridge, MA USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 1278 - 1287
SICI:
0014-2980(200104)31:4<1278:IOOTTC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PERIPHERAL LYMPHOID ORGANS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; INTESTINAL EPITHELIAL-CELLS; ALPHA-DEFICIENT MICE; SUPPRESSOR T-CELLS; LYMPHOTOXIN-ALPHA; ANTIGEN; BETA; EXPRESSION;
Keywords:
tolerance/suppression; lymph node; transgenic/knockout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, HL 77 Ave Louis Pasteur,HIM 730, Boston, MA 02115 USA 77 Ave Louis Pasteur,HIM 730 Boston MA USA 02115 MA 02115 USA
Citazione:
T.W. Spahn et al., "Induction of oral tolerance to cellular immune responses in the absence ofPeyer's patches", EUR J IMMUN, 31(4), 2001, pp. 1278-1287

Abstract

Systemic hyporesponsiveness occurs following oral administration of antigen (oral tolerance) and involves the uptake and processing of antigen by thegut-associated lymphoid tissue (GALT), which includes Peyer's patches (PP)lamina propria lymphocytes and mesenteric lymph nodes (MLN). Animals with targeted mutations of genes in the tumor necrosis factor (TNF) family have differential defects in the development of peripheral lymphoid organs including PP and MLN, and provide a unique opportunity to investigate the role of GALT structures in the induction of oral tolerance. Oral tolerance could not be induced in TNF/lymphotoxin (LT) alpha-/- mice, which are devoid of both PP and MLN, although these animals could be tolerized by intraperitoneal administration of antigen, demonstrating the requirement for GALT for oral tolerance induction. LT beta-/- mice and LT alpha /LT beta+/- animals do not have PP but could be orally tolerized, as measured by IFN-gamma production and delayed-type hypersensitivity responses by administration of both low or high doses of ovalbumin. To further investigate the requirement for PP, we tested the progeny of LTP-receptor-IgG-fusion-protein (LT beta RigG)-treated mice, which do not form PP but have an otherwise intact immune system. Although these animals had decreased fecal IgA production, they could be orally tolerized. Our results demonstrate that PP are not an absolute requirement for the induction of either high- or low-dose oral tolerance, although oral tolerance could not be induced in animals devoid of both PP and MLN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:28:10