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Titolo:
Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
Autore:
Stephens, LA; Mottet, C; Mason, C; Powrie, F;
Indirizzi:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England Univ Oxford, Nuffield Dept Surg, Oxford, England Univ Oxford Oxford England Oxford, Nuffield Dept Surg, Oxford, England
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 1247 - 1254
SICI:
0014-2980(200104)31:4<1247:HCTAPT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL SELF-TOLERANCE; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; GROWTH-FACTOR-BETA; INTESTINAL INFLAMMATION; HUMAN THYMUS; IN-VITRO; AUTOIMMUNITY; INTERLEUKIN-4; EXPRESSION; ACTIVATION;
Keywords:
regulation; tolerance; T cell; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Stephens, LA Univ Oxford, Sir William Dunn Sch Pathol, S Parks Rd, Oxford OX1 3RE, England Univ Oxford S Parks Rd Oxford England OX1 3RE 1 3RE, England
Citazione:
L.A. Stephens et al., "Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro", EUR J IMMUN, 31(4), 2001, pp. 1247-1254

Abstract

CD4(+)CD25(+) T cells in mice and rats are capable of transferring protection against organ-specific autoimmune disease and colitis and suppressing the proliferation of other T cells after polyclonal stimulation in vitro. Here we describe the existence in humans of CD4(+)CD25(+) T cells with the same in vitro characteristics. CD4(+)CD8(-)CD25(+) T cells are present in both the thymus and peripheral blood of humans (similar to 10 % of CD4(+)CD8(-) T cells), proliferate poorly in response to mitogenic stimulation and suppress the proliferation of CD4(+)CD25(-) cells in coculture. This suppression requires cell contact and can be overcome by the addition of exogenous IL-2. CD4(+)CD25(+) cells from thymus and blood were poor producers of IL-2 and IFN-gamma, and suppressed the levels of these cytokines produced by CD4(+)CD25(-) cells. However, CD4(+)CD25(+) PBL produced higher levels of IL-4and similar amounts of IL-10 as CD4(+)CD25(-) cells. Regulatory CD4(+)CD25(+) T cells have an activated phenotype in the thymus with expression of CTLA-4 and CD122 (IL-2R beta). The fact that CD4(+)CD25(+) regulatory T cellsare present with a similar frequency in the thymus of humans, rats and mice, suggests that the role of these cells in the maintenance of immunological tolerance is an evolutionarily conserved mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:59:20